Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in cellular response to tumor necrosis factor; negative regulation of apoptotic process; and regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZFAND6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFAND6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFAND6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:79,896,444–79,897,502 | 162.7 kb | Distal (>10kb) Multiome | 983 | |
| chr15:79,922,798–79,924,291 | 135.8 kb | Distal (>10kb) Multiome | 898 | |
| chr15:80,042,284–80,043,445 | 16.8 kb | Distal (>10kb) Multiome | 46 | |
| chr15:80,058,797–80,060,366 | 60 bp | At TSS Multiome | 899 | |
| chr15:80,151,875–80,153,515 | 93.0 kb | Distal (>10kb) Multiome | 652 | |
| chr15:80,242,196–80,242,881 | 182.8 kb | Distal (>10kb) Multiome | 225 | |
| chr15:80,316,749–80,317,252 | 257.5 kb | Distal (>10kb) Multiome | 24 |
Genomic view of the ZFAND6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.