This module contains 13 genes including SEC14L2, RNF170, FBXO16, PHYKPL, and TTC23, with top enrichment in ubiquitin-mediated proteolysis and protein modification pathways. Knockdown of FOXA2 activates this module, while knockdown of SOX17 and EOMES represses it.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.