This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for BNIP3L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BNIP3L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BNIP3L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:26,290,938–26,292,152 | 91.6 kb | Distal (>10kb) Multiome | 690 | |
| chr8:26,374,061–26,374,379 | 8.7 kb | Proximal (<10kb) | 243 | |
| chr8:26,382,644–26,384,037 | 235 bp | At TSS Multiome | 915 | |
| chr8:26,448,172–26,450,526 | 66.4 kb | Distal (>10kb) Multiome | 708 | |
| chr8:26,513,536–26,515,319 | 132.1 kb | Distal (>10kb) Multiome | 359 | |
| chr8:26,576,275–26,578,173 | 194.7 kb | Distal (>10kb) Multiome | 854 | |
| chr8:26,641,298–26,642,123 | 258.8 kb | Distal (>10kb) Multiome | 636 | |
| chr8:26,661,625–26,662,109 | 278.9 kb | Distal (>10kb) Multiome | 240 |
Genomic view of the BNIP3L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.