Enables guanylyltransferase activity; poly(A) RNA polymerase activity; and telomerase RNA binding activity. Involved in RNA metabolic process; carbohydrate homeostasis; and regulation of nucleobase-containing compound metabolic process. Located in cytosol; nucleolus; and plasma membrane. Part of TRAMP complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TENT4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TENT4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TENT4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:49,854,387–49,856,396 | 297.7 kb | Distal (>10kb) Multiome | 495 | |
| chr16:49,856,552–49,859,437 | 296.1 kb | Distal (>10kb) Multiome | 535 | |
| chr16:49,876,274–49,877,137 | 276.5 kb | Distal (>10kb) Multiome | 296 | |
| chr16:50,024,713–50,025,833 | 128.1 kb | Distal (>10kb) Multiome | 882 | |
| chr16:50,065,596–50,066,866 | 87.2 kb | Distal (>10kb) Multiome | 839 | |
| chr16:50,152,387–50,154,528 | 196 bp | At TSS Multiome | 930 | |
| chr16:50,368,327–50,369,672 | 215.7 kb | Distal (>10kb) Multiome | 596 |
Genomic view of the TENT4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.