This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for AGO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AGO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AGO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:140,456,908–140,458,690 | 177.7 kb | Distal (>10kb) Multiome | 958 | |
| chr8:140,463,628–140,465,358 | 171.0 kb | Distal (>10kb) Multiome HiCAR | 951 | |
| chr8:140,510,454–140,512,419 | 123.8 kb | Distal (>10kb) Multiome | 1085 | |
| chr8:140,634,296–140,636,707 | 373 bp | At TSS Multiome | 750 | |
| chr8:140,637,252–140,637,924 | 2.0 kb | Proximal (<10kb) Multiome | 409 |
Genomic view of the AGO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.