Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPSB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPSB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPSB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:9,128,169–9,129,971 | 163.5 kb | Distal (>10kb) Multiome | 749 | |
| chr1:9,181,345–9,181,788 | 111.4 kb | Distal (>10kb) Multiome | 423 | |
| chr1:9,234,085–9,235,495 | 58.2 kb | Distal (>10kb) Multiome | 911 | |
| chr1:9,292,267–9,293,831 | 81 bp | At TSS Multiome | 521 | |
| chr1:9,319,794–9,320,541 | 27.3 kb | Distal (>10kb) Multiome | 91 | |
| chr1:9,374,739–9,375,309 | 82.1 kb | Distal (>10kb) Multiome | 121 | |
| chr1:9,428,560–9,429,575 | 136.1 kb | Distal (>10kb) Multiome | 815 | |
| chr1:9,495,048–9,495,686 | 202.5 kb | Distal (>10kb) Multiome HiCAR | 606 | |
| chr1:9,538,797–9,540,343 | 246.5 kb | Distal (>10kb) Multiome | 879 | |
| chr1:9,588,272–9,589,797 | 295.8 kb | Distal (>10kb) Multiome | 633 |
Genomic view of the SPSB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.