This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for ITPK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITPK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITPK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:92,922,929–92,923,801 | 191.9 kb | Distal (>10kb) Multiome | 736 | |
| chr14:93,112,888–93,113,057 | 2.2 kb | Proximal (<10kb) | 171 | |
| chr14:93,113,179–93,113,307 | 2.0 kb | Proximal (<10kb) | 148 | |
| chr14:93,113,409–93,113,585 | 1.7 kb | Proximal (<10kb) | 234 | |
| chr14:93,114,737–93,116,548 | 203 bp | At TSS Multiome | 614 | |
| chr14:93,184,056–93,185,524 | 69.6 kb | Distal (>10kb) Multiome | 831 | |
| chr14:93,206,605–93,207,773 | 91.9 kb | Distal (>10kb) Multiome | 809 | |
| chr14:93,332,195–93,333,678 | 217.7 kb | Distal (>10kb) Multiome | 770 |
Genomic view of the ITPK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.