Enables ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of canonical NF-kappaB signal transduction; and protein K48-linked ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CUL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CUL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CUL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:148,501,343–148,502,380 | 196.9 kb | Distal (>10kb) Multiome | 188 | |
| chr7:148,698,154–148,700,147 | 1.0 kb | Proximal (<10kb) Multiome | 840 | |
| chr7:148,704,964–148,705,256 | 6.3 kb | Proximal (<10kb) | 47 | |
| chr7:148,883,285–148,885,276 | 185.5 kb | Distal (>10kb) Multiome | 917 | |
| chr7:148,940,713–148,941,315 | 242.2 kb | Distal (>10kb) Multiome | 792 | |
| chr7:148,966,846–148,967,346 | 268.2 kb | Distal (>10kb) Multiome | 532 | |
| chr7:148,982,929–148,984,226 | 284.8 kb | Distal (>10kb) Multiome | 671 | |
| chr7:148,987,066–148,988,336 | 288.7 kb | Distal (>10kb) Multiome | 765 |
Genomic view of the CUL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.