Enables ribosome binding activity. Involved in positive regulation of mRNA catabolic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:20,305,280–20,306,297 | at TSS | At TSS | 708 | |
| chr14:20,332,742–20,333,665 | 27.2 kb | Distal (>10kb) Multiome | 694 | |
| chr14:20,342,187–20,344,100 | 37.4 kb | Distal (>10kb) Multiome | 1112 | |
| chr14:20,412,688–20,413,758 | 107.4 kb | Distal (>10kb) Multiome | 865 | |
| chr14:20,454,384–20,455,825 | 149.1 kb | Distal (>10kb) Multiome | 1012 | |
| chr14:20,460,777–20,462,259 | 155.7 kb | Distal (>10kb) Multiome | 995 | |
| chr14:20,468,846–20,470,856 | 163.4 kb | Distal (>10kb) Multiome | 950 | |
| chr14:20,494,584–20,495,486 | 189.1 kb | Distal (>10kb) Multiome | 201 |
Genomic view of the TTC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.