This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TERF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TERF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TERF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:69,105,371–69,107,181 | 278.4 kb | Distal (>10kb) Multiome | 631 | |
| chr16:69,131,353–69,133,059 | 252.2 kb | Distal (>10kb) Multiome | 961 | |
| chr16:69,170,078–69,170,680 | 214.3 kb | Distal (>10kb) Multiome | 43 | |
| chr16:69,186,569–69,187,845 | 197.5 kb | Distal (>10kb) Multiome | 878 | |
| chr16:69,310,637–69,312,153 | 73.4 kb | Distal (>10kb) Multiome | 963 | |
| chr16:69,329,919–69,331,310 | 54.0 kb | Distal (>10kb) Multiome | 977 | |
| chr16:69,339,182–69,340,174 | 45.0 kb | Distal (>10kb) Multiome | 1014 | |
| chr16:69,385,555–69,386,170 | 1.3 kb | Proximal (<10kb) Multiome | 857 | |
| chr16:69,424,128–69,425,019 | 39.9 kb | Distal (>10kb) Multiome | 907 | |
| chr16:69,529,449–69,529,941 | 145.1 kb | Distal (>10kb) Multiome | 450 | |
| chr16:69,565,464–69,566,984 | 181.2 kb | Distal (>10kb) Multiome | 1044 | |
| chr16:69,726,315–69,727,097 | 341.9 kb | Distal (>10kb) Multiome HiCAR | 879 |
Genomic view of the TERF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.