This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for FBXO16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:28,318,563–28,319,487 | 171.3 kb | Distal (>10kb) Multiome | 205 | |
| chr8:28,384,745–28,386,965 | 103.8 kb | Distal (>10kb) Multiome | 674 | |
| chr8:28,401,081–28,402,986 | 88.1 kb | Distal (>10kb) Multiome | 941 | |
| chr8:28,411,636–28,412,462 | 78.2 kb | Distal (>10kb) Multiome | 805 | |
| chr8:28,429,151–28,429,912 | 60.7 kb | Distal (>10kb) Multiome | 77 | |
| chr8:28,490,087–28,490,872 | 136 bp | At TSS Multiome | 535 | |
| chr8:28,493,649–28,495,132 | 4.0 kb | Proximal (<10kb) Multiome | 656 | |
| chr8:28,622,031–28,623,620 | 132.3 kb | Distal (>10kb) Multiome | 828 | |
| chr8:28,700,738–28,702,456 | 211.3 kb | Distal (>10kb) Multiome | 728 |
Genomic view of the FBXO16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.