Enables identical protein binding activity. Involved in endoplasmic reticulum tubular network maintenance and positive regulation of endoplasmic reticulum tubular network organization. Located in endoplasmic reticulum tubular network membrane and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LNPK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LNPK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LNPK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:175,980,827–175,982,249 | 20.8 kb | Distal (>10kb) Multiome | 156 | |
| chr2:176,001,269–176,002,875 | 1 bp | At TSS Multiome | 1003 | |
| chr2:176,079,159–176,081,284 | 77.9 kb | Distal (>10kb) Multiome | 591 | |
| chr2:176,082,698–176,083,714 | 81.0 kb | Distal (>10kb) Multiome | 171 | |
| chr2:176,087,237–176,089,163 | 86.3 kb | Distal (>10kb) Multiome | 475 | |
| chr2:176,091,485–176,093,664 | 90.4 kb | Distal (>10kb) Multiome | 351 | |
| chr2:176,096,693–176,099,096 | 95.4 kb | Distal (>10kb) Multiome | 661 | |
| chr2:176,106,474–176,108,077 | 105.1 kb | Distal (>10kb) Multiome | 426 | |
| chr2:176,115,942–176,116,781 | 114.2 kb | Distal (>10kb) Multiome | 202 | |
| chr2:176,122,221–176,123,570 | 120.5 kb | Distal (>10kb) Multiome | 242 | |
| chr2:176,140,289–176,141,245 | 138.5 kb | Distal (>10kb) Multiome | 712 | |
| chr2:176,158,845–176,160,665 | 156.8 kb | Distal (>10kb) Multiome | 325 | |
| chr2:176,171,283–176,172,596 | 169.6 kb | Distal (>10kb) Multiome | 245 | |
| chr2:176,174,987–176,175,675 | 172.9 kb | Distal (>10kb) Multiome | 273 | |
| chr2:176,177,721–176,178,875 | 176.0 kb | Distal (>10kb) Multiome | 271 | |
| chr2:176,188,129–176,189,887 | 186.4 kb | Distal (>10kb) Multiome | 652 | |
| chr2:176,269,105–176,270,145 | 267.2 kb | Distal (>10kb) Multiome | 1001 |
Genomic view of the LNPK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.