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DE-5.20

Submodule 12 genes

Ribonucleoprotein granule assembly and dynamics

This module contains 12 genes including DHX9, SRPK1, EIF3A, and DDX6, enriched for ribonucleoprotein granule components. No transcription factor knockdown data are available for this module, limiting interpretation of its regulatory control during ESC-to-endoderm differentiation. The biological role of these genes in endoderm formation remains to be determined through additional functional studies.

Key terms: viral process viral genome packaging ribonucleoprotein complex biogenesis viral RNA genome packaging Notable genes: DHX9 SRPK1 EIF3A DDX6 AMD1 TCERG1 NAA15 DHX15

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (12)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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