This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for PRMT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRMT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRMT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:68,019,222–68,020,043 | 291.6 kb | Distal (>10kb) Multiome | 108 | |
| chr16:68,022,490–68,023,556 | 287.8 kb | Distal (>10kb) Multiome | 958 | |
| chr16:68,084,205–68,086,133 | 225.8 kb | Distal (>10kb) Multiome | 1092 | |
| chr16:68,235,016–68,238,254 | 74.9 kb | Distal (>10kb) Multiome | 1055 | |
| chr16:68,239,582–68,240,355 | 71.0 kb | Distal (>10kb) Multiome | 223 | |
| chr16:68,244,730–68,245,757 | 65.8 kb | Distal (>10kb) Multiome | 803 | |
| chr16:68,264,033–68,265,087 | 46.6 kb | Distal (>10kb) Multiome HiCAR | 876 | |
| chr16:68,310,451–68,311,505 | 31 bp | At TSS Multiome | 1061 | |
| chr16:68,328,654–68,329,423 | 17.7 kb | Distal (>10kb) Multiome | 438 | |
| chr16:68,420,400–68,420,906 | 109.5 kb | Distal (>10kb) Multiome | 58 | |
| chr16:68,447,981–68,449,250 | 137.6 kb | Distal (>10kb) Multiome | 795 | |
| chr16:68,520,489–68,521,019 | 209.7 kb | Distal (>10kb) Multiome | 602 | |
| chr16:68,528,418–68,529,128 | 217.7 kb | Distal (>10kb) Multiome | 552 | |
| chr16:68,529,733–68,530,671 | 219.1 kb | Distal (>10kb) Multiome | 831 | |
| chr16:68,538,873–68,540,027 | 228.2 kb | Distal (>10kb) Multiome | 764 |
Genomic view of the PRMT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.