This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for LPCAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LPCAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LPCAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:1,294,274–1,295,675 | 228.8 kb | Distal (>10kb) Multiome | 415 | |
| chr5:1,344,394–1,345,745 | 178.9 kb | Distal (>10kb) Multiome | 652 | |
| chr5:1,385,584–1,386,611 | 138.0 kb | Distal (>10kb) Multiome | 420 | |
| chr5:1,444,671–1,446,554 | 78.5 kb | Distal (>10kb) Multiome | 180 | |
| chr5:1,514,802–1,515,092 | 8.9 kb | Proximal (<10kb) | 138 | |
| chr5:1,523,066–1,524,710 | 130 bp | At TSS Multiome | 630 | |
| chr5:1,593,846–1,595,021 | 70.6 kb | Distal (>10kb) Multiome HiCAR | 682 | |
| chr5:1,633,700–1,634,325 | 110.0 kb | Distal (>10kb) Multiome | 745 | |
| chr5:1,644,948–1,645,570 | 121.2 kb | Distal (>10kb) Multiome | 437 | |
| chr5:1,666,897–1,668,526 | 143.4 kb | Distal (>10kb) Multiome | 301 | |
| chr5:1,799,167–1,800,245 | 275.9 kb | Distal (>10kb) Multiome | 744 | |
| chr5:1,800,343–1,801,861 | 277.4 kb | Distal (>10kb) Multiome | 895 |
Genomic view of the LPCAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.