This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphohydroxylysinuria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for PHYKPL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHYKPL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHYKPL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:178,075,958–178,076,432 | 156.3 kb | Distal (>10kb) Multiome | 336 | |
| chr5:178,113,136–178,114,807 | 119.0 kb | Distal (>10kb) Multiome | 620 | |
| chr5:178,130,402–178,131,452 | 101.6 kb | Distal (>10kb) Multiome | 875 | |
| chr5:178,153,562–178,154,391 | 78.5 kb | Distal (>10kb) Multiome | 695 | |
| chr5:178,164,084–178,164,721 | 68.1 kb | Distal (>10kb) Multiome | 514 | |
| chr5:178,179,895–178,180,860 | 52.2 kb | Distal (>10kb) Multiome | 283 | |
| chr5:178,203,935–178,205,708 | 28.2 kb | Distal (>10kb) Multiome | 995 | |
| chr5:178,231,971–178,233,141 | 100 bp | At TSS Multiome | 764 | |
| chr5:178,235,108–178,235,300 | 2.3 kb | Proximal (<10kb) | 184 | |
| chr5:178,470,038–178,470,701 | 238.0 kb | Distal (>10kb) Multiome | 49 | |
| chr5:178,589,202–178,590,958 | 358.0 kb | Distal (>10kb) Multiome HiCAR | 378 |
Genomic view of the PHYKPL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.