Enables ATPase binding activity. Involved in dendrite morphogenesis and lysosome localization. Located in endosome and lysosomal membrane. Implicated in hypomyelinating leukodystrophy 16. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM106B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM106B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM106B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:12,111,216–12,112,364 | 99.4 kb | Distal (>10kb) Multiome | 258 | |
| chr7:12,210,198–12,212,416 | 52 bp | At TSS Multiome | 1158 | |
| chr7:12,329,006–12,329,738 | 118.1 kb | Distal (>10kb) Multiome | 220 | |
| chr7:12,403,223–12,404,775 | 192.5 kb | Distal (>10kb) Multiome | 590 | |
| chr7:12,423,909–12,424,530 | 213.0 kb | Distal (>10kb) Multiome | 203 |
Genomic view of the TMEM106B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.