This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Transcription factors with Perturb-seq knockdown data for IGF2BP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGF2BP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGF2BP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:48,718,468–48,719,563 | 278.6 kb | Distal (>10kb) Multiome | 164 | |
| chr17:48,719,708–48,720,337 | 277.5 kb | Distal (>10kb) Multiome | 181 | |
| chr17:48,722,219–48,723,762 | 274.5 kb | Distal (>10kb) Multiome | 220 | |
| chr17:48,728,286–48,729,570 | 268.6 kb | Distal (>10kb) Multiome | 376 | |
| chr17:48,816,754–48,817,592 | 180.3 kb | Distal (>10kb) Multiome | 589 | |
| chr17:48,830,670–48,831,519 | 166.4 kb | Distal (>10kb) Multiome | 838 | |
| chr17:48,891,910–48,893,540 | 104.9 kb | Distal (>10kb) Multiome | 1059 | |
| chr17:48,907,825–48,909,317 | 89.2 kb | Distal (>10kb) Multiome | 1011 | |
| chr17:48,944,483–48,945,203 | 52.6 kb | Distal (>10kb) Multiome | 1009 | |
| chr17:48,995,124–48,997,874 | 105 bp | At TSS Multiome | 1057 | |
| chr17:49,003,702–49,004,102 | 6.2 kb | Proximal (<10kb) | 276 | |
| chr17:49,013,253–49,014,714 | 16.6 kb | Distal (>10kb) Multiome | 480 | |
| chr17:49,022,149–49,022,993 | 25.1 kb | Distal (>10kb) Multiome | 306 | |
| chr17:49,031,811–49,032,444 | 34.8 kb | Distal (>10kb) Multiome | 423 | |
| chr17:49,035,641–49,036,299 | 38.5 kb | Distal (>10kb) Multiome | 338 | |
| chr17:49,191,794–49,193,465 | 195.3 kb | Distal (>10kb) Multiome | 1177 | |
| chr17:49,223,535–49,224,633 | 226.3 kb | Distal (>10kb) Multiome | 281 | |
| chr17:49,230,380–49,231,209 | 233.4 kb | Distal (>10kb) Multiome | 496 | |
| chr17:49,260,115–49,260,840 | 262.9 kb | Distal (>10kb) Multiome | 480 |
Genomic view of the IGF2BP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.