This module contains 24 genes including VHL, DNMT3A, RXRA, and TERF2, with enrichment in histone modification and epigenetic regulation. Knockdown of PREB represses this module, suggesting PREB supports the expression of genes involved in chromatin remodeling and DNA methylation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.