The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GOLPH3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOLPH3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOLPH3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:32,173,339–32,175,075 | 31 bp | At TSS Multiome | 1090 | |
| chr5:32,287,695–32,288,492 | 113.9 kb | Distal (>10kb) Multiome | 161 | |
| chr5:32,312,016–32,313,764 | 138.8 kb | Distal (>10kb) Multiome | 877 | |
| chr5:32,443,333–32,445,482 | 270.4 kb | Distal (>10kb) Multiome | 960 | |
| chr5:32,463,190–32,463,817 | 289.3 kb | Distal (>10kb) Multiome | 67 | |
| chr5:32,474,004–32,474,924 | 300.1 kb | Distal (>10kb) Multiome | 130 |
Genomic view of the GOLPH3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.