chr19:2,581,128–2,581,843

chr19 : 2,581,128 – 2,581,843

715 bp 206 TFs 12 linked genes

This 715 bp open chromatin element is linked to 12 target genes and is bound by 206 transcription factors.

Linked Genes

12 genes

Gene	Expression	Dist. to TSS	Distance	Link type
GADD45B		105.3 kb	Distal	Multiome+HiCAR
GNG7		121.3 kb	Distal	Multiome
LMNB2		124.4 kb	Distal	Multiome
TIMM13		153.8 kb	Distal	Multiome
SLC39A3		158.6 kb	Distal	Multiome
SGTA		201.9 kb	Distal	Multiome
THOP1		204.1 kb	Distal	Multiome
ZNF554		238.5 kb	Distal	Multiome
SPPL2B		252.7 kb	Distal	Multiome
LSM7		252.8 kb	Distal	Multiome
ZNF555		260.1 kb	Distal	Multiome
LINGO3		273.2 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

206 transcription factors

ChIP LNCaP GSE80256.AR.LNCaP 274 bp overlap

ARNT2 1 dataset

Motif DE_24h DE_24h-ARNT2_MA1464.2 8 bp overlap

ARNT::HIF1A 1 dataset

Motif DE_24h DE_24h-ARNTHIF1A_MA0259.2 5 bp overlap

ASH2L 1 dataset

ChIP WA01 ENCSR850KIP.ASH2L.WA01 375 bp overlap

Motif DE_24h DE_24h-Arnt_MA0004.1 6 bp overlap

Ascl2 1 dataset

Motif DE_24h DE_24h-Ascl2_MA0816.1 10 bp overlap

BACH1 2 datasets

ChIP H1 ENCFF282VDB 321 bp overlap

ChIP WA01 ENCSR000EBQ.BACH1.WA01 207 bp overlap

BCOR 4 datasets

ChIP WA01 GSE104690.BCOR.WA01 521 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 400 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 286 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 293 bp overlap

BHLHE40 1 dataset

ChIP IMR-90 ENCSR957KYB.BHLHE40.IMR-90 140 bp overlap

ChIP MV4-11_IBET151_50nM GSE120715.BRD3.MV4-11_IBET151_50nM 150 bp overlap

BRD4 3 datasets

ChIP K-562_iBET-BD1-IFNG GSE138084.BRD4.K-562_iBET-BD1-IFNG 178 bp overlap

ChIP LPS141 GSE111253.BRD4.LPS141 201 bp overlap

ChIP MCF-7_ARID1A-KO GSE123284.BRD4.MCF-7_ARID1A-KO 386 bp overlap

Bcl11B 1 dataset

Motif DE_24h DE_24h-Bcl11B_MA1989.2 9 bp overlap

ChIP A-549 ENCSR550SCU.CHD4.A-549 124 bp overlap

CLOCK 1 dataset

Motif DE_24h DE_24h-CLOCK_MA0819.3 7 bp overlap

CTCF 122 datasets

ChIP 786-O_NORMOXIA GSE78113.CTCF.786-O_NORMOXIA 360 bp overlap

ChIP A-549 ENCSR000DPF.CTCF.A-549 160 bp overlap

ChIP AG04449 ENCFF248MBD 181 bp overlap

ChIP BJ ENCFF434HEC 311 bp overlap

ChIP BJ ENCSR000DQI.CTCF.BJ 199 bp overlap

ChIP CD14-positive monocyte ENCFF087XLR 353 bp overlap

ChIP CD14-positive monocyte ENCFF087XLR 645 bp overlap

ChIP D54 ENCSR000DKN.CTCF.D54 121 bp overlap

Motif DE_24h DE_24h-CTCF_MA0139.2 15 bp overlap

Motif DE_24h DE_24h-CTCF_MA1930.2 33 bp overlap

ChIP DOHH2 ENCSR084RDK.CTCF.DOHH2 248 bp overlap

ChIP GM04025_B-lymphocytes GSE111170.CTCF.GM04025_B-lymphocytes 144 bp overlap

ChIP GM04604 GSE148179.CTCF.GM04604 152 bp overlap

ChIP GM09236__B-lymphocytes GSE111170.CTCF.GM09236__B-lymphocytes 135 bp overlap

ChIP GM13977 ENCFF528ESQ 171 bp overlap

ChIP GM17942 GSE76922.CTCF.GM17942 262 bp overlap

ChIP GM23338 ENCFF772DML 104 bp overlap

ChIP H1 ENCFF230QSV 165 bp overlap

ChIP H1 ENCFF414GZI 217 bp overlap

ChIP H1 ENCFF764RHO 277 bp overlap

ChIP H9 ENCFF152GTF 261 bp overlap

ChIP HCT-116 ENCSR000DTO.CTCF.HCT-116 132 bp overlap

ChIP HCT-116 GSE131606.CTCF.HCT-116 308 bp overlap

ChIP HCT-116_RAD21-mAC GSE104888.CTCF.HCT-116_RAD21-mAC 434 bp overlap

ChIP HEK293 ENCSR000DTW.CTCF.HEK293 106 bp overlap

ChIP HL-60 GSE131577.CTCF.HL-60 117 bp overlap

ChIP HT-1080 GSE135580.CTCF.HT-1080 231 bp overlap

ChIP HeLa-S3 ENCFF565UFR 161 bp overlap

ChIP HeLa-S3 ENCSR000DUB.CTCF.HeLa-S3 132 bp overlap

ChIP HeLa-S3 ENCSR000DLO.CTCF.HeLa-S3 103 bp overlap

ChIP HeLa-S3_shCtrl GSE137848.CTCF.HeLa-S3_shCtrl 213 bp overlap

ChIP HeLa_dC9Sun-D3A_CDCC85C GSE107607.CTCF.HeLa_dC9Sun-D3A_CDCC85C 126 bp overlap

ChIP Hep-G2 ENCSR000BIE.CTCF.Hep-G2 138 bp overlap

ChIP Hep-G2 ENCSR000DLS.CTCF.Hep-G2 117 bp overlap

ChIP Hep-G2 ENCSR000AMA.CTCF.Hep-G2 158 bp overlap

ChIP Hep-G2 ENCSR000DUG.CTCF.Hep-G2 133 bp overlap

ChIP HepG2 ENCFF127KUP 231 bp overlap

ChIP HepG2 ENCFF348BUL 197 bp overlap

ChIP HepG2 ENCFF668CTD 145 bp overlap

ChIP HepG2 ENCFF757EKU 351 bp overlap

ChIP IMR-90 ENCSR000EFI.CTCF.IMR-90 169 bp overlap

ChIP IMR-90 GSE43070.CTCF.IMR-90 158 bp overlap

ChIP K-562 ENCSR000EGM.CTCF.K-562 142 bp overlap

ChIP K-562 GSE70764.CTCF.K-562 220 bp overlap

ChIP K-562 ENCSR000DMA.CTCF.K-562 105 bp overlap

ChIP K-562 ENCSR000BPJ.CTCF.K-562 121 bp overlap

ChIP K-562 ENCSR000DWE.CTCF.K-562 145 bp overlap

ChIP K-562 GSE92879.CTCF.K-562 220 bp overlap

ChIP K-562_14376 GSE131349.CTCF.K-562_14376 97 bp overlap

ChIP K-562_15776 GSE131349.CTCF.K-562_15776 101 bp overlap

ChIP K-562_7140 GSE131349.CTCF.K-562_7140 121 bp overlap

ChIP K-562_CRISPRa_N4293 GSE131349.CTCF.K-562_CRISPRa_N4293 119 bp overlap

ChIP K-562_CRISPRk_N4293 GSE131349.CTCF.K-562_CRISPRk_N4293 133 bp overlap

ChIP K-562_MonoC GSE137216.CTCF.K-562_MonoC 253 bp overlap

ChIP K-562_RF2-insertion GSE140868.CTCF.K-562_RF2-insertion 99 bp overlap

ChIP K562 ENCFF400DFR 241 bp overlap

ChIP K562 ENCFF598YSU 271 bp overlap

ChIP Loucy ENCSR464DKE.CTCF.Loucy 185 bp overlap

ChIP MCF-7 ENCFF954TUV 205 bp overlap

ChIP MCF-7 ENCSR000AHD.CTCF.MCF-7 132 bp overlap

ChIP MM1-S GSE43743.CTCF.MM1-S 488 bp overlap

ChIP NB69 GSE101295.CTCF.NB69 168 bp overlap

ChIP OCI-Ly3 ENCSR756ZKG.CTCF.OCI-Ly3 181 bp overlap

ChIP OVCAR-8 GSE70764.CTCF.OVCAR-8 162 bp overlap

ChIP PC-3 ENCSR359LOD.CTCF.PC-3 225 bp overlap

ChIP SK-MEL-147 GSE94488.CTCF.SK-MEL-147 102 bp overlap

ChIP SK-N-SH ENCSR000DXQ.CTCF.SK-N-SH 122 bp overlap

ChIP SK-N-SH ENCSR000BLX.CTCF.SK-N-SH 108 bp overlap

ChIP SK-N-SH ENCSR000EIC.CTCF.SK-N-SH 149 bp overlap

ChIP THP-1_Pam3csk-000m-Flavo-000m GSE103477.CTCF.THP-1_Pam3csk-000m-Flavo-000m 257 bp overlap

ChIP THP-1_Pam3csk-000m-Flavo-240m GSE103477.CTCF.THP-1_Pam3csk-000m-Flavo-240m 235 bp overlap

ChIP THP-1_Pam3csk-020m-Flavo-000m GSE103477.CTCF.THP-1_Pam3csk-020m-Flavo-000m 190 bp overlap

ChIP THP-1_Pam3csk-025m-Flavo-000m GSE103477.CTCF.THP-1_Pam3csk-025m-Flavo-000m 160 bp overlap

ChIP THP-1_Pam3csk-120m-Flavo-000m GSE103477.CTCF.THP-1_Pam3csk-120m-Flavo-000m 158 bp overlap

ChIP THP-1_Pam3csk-150m-Flavo-030m GSE103477.CTCF.THP-1_Pam3csk-150m-Flavo-030m 180 bp overlap

ChIP THP-1_Pam3csk-180m-Flavo-060m GSE103477.CTCF.THP-1_Pam3csk-180m-Flavo-060m 275 bp overlap

ChIP THP-1_Pam3csk-360m-Flavo-240m GSE103477.CTCF.THP-1_Pam3csk-360m-Flavo-240m 283 bp overlap

ChIP THP-1_siCtrl-eGFP-Pam3csk-0h GSE103477.CTCF.THP-1_siCtrl-eGFP-Pam3csk-0h 264 bp overlap

ChIP WA01 ENCSR000DLK.CTCF.WA01 140 bp overlap

ChIP WA01 ENCSR000BNH.CTCF.WA01 158 bp overlap

ChIP WERI-Rb-1 ENCFF349QKF 231 bp overlap

ChIP WERI-Rb-1 ENCSR000DXW.CTCF.WERI-Rb-1 143 bp overlap

ChIP astrocyte_spinal_cord ENCSR000DSU.CTCF.astrocyte_spinal_cord 111 bp overlap

ChIP brain ENCFF163BBN 572 bp overlap

ChIP cardiac-muscle ENCSR713SXF.CTCF.cardiac-muscle 183 bp overlap

ChIP chondrocyte ENCFF134ORZ 256 bp overlap

ChIP choroid plexus epithelial cell ENCFF407YNR 277 bp overlap

ChIP choroid-plexus_epithelial ENCSR000DTL.CTCF.choroid-plexus_epithelial 164 bp overlap

ChIP endodermal cell ENCFF471YCZ 273 bp overlap

ChIP endothelial_brain-microvascular ENCSR000DTA.CTCF.endothelial_brain-microvascular 142 bp overlap

ChIP endothelial_umbilical-vein ENCSR000DVP.CTCF.endothelial_umbilical-vein 167 bp overlap

ChIP epithelial_retinal_pigment ENCSR000DVI.CTCF.epithelial_retinal_pigment 116 bp overlap

ChIP erythroid GSE67783.CTCF.erythroid 210 bp overlap

ChIP fibroblast of lung ENCFF084DUH 131 bp overlap

ChIP fibroblast_CARDIAC ENCSR000DTF.CTCF.fibroblast_CARDIAC 137 bp overlap

ChIP fibroblast_FORESKIN ENCSR000DUH.CTCF.fibroblast_FORESKIN 160 bp overlap

ChIP fibroblast_GINGIVA ENCSR000DPS.CTCF.fibroblast_GINGIVA 124 bp overlap

ChIP fibroblast_PULMONARY_ARTERY ENCSR000DUX.CTCF.fibroblast_PULMONARY_ARTERY 132 bp overlap

ChIP fibroblast_SKIN_LEG ENCSR000DPG.CTCF.fibroblast_SKIN_LEG 113 bp overlap

ChIP gastroesophageal sphincter ENCFF607YRA 445 bp overlap

ChIP hESC_D0 GSE116862.CTCF.hESC_D0 225 bp overlap

ChIP hESC_D2 GSE116862.CTCF.hESC_D2 290 bp overlap

ChIP hESC_D5 GSE116862.CTCF.hESC_D5 424 bp overlap

ChIP hepatocyte ERP000395.CTCF.hepatocyte 133 bp overlap

ChIP hiPSC_CVI GSE106870.CTCF.hiPSC_CVI 171 bp overlap

ChIP hiPSC_IB12 GSE106870.CTCF.hiPSC_IB12 192 bp overlap

ChIP hiPSC_IB7 GSE106870.CTCF.hiPSC_IB7 182 bp overlap

ChIP hiPSC_IIA11 GSE106870.CTCF.hiPSC_IIA11 193 bp overlap

ChIP hiPSC_IID12 GSE106870.CTCF.hiPSC_IID12 145 bp overlap

ChIP hiPSC_IV8 GSE106870.CTCF.hiPSC_IV8 200 bp overlap

ChIP hiPSC_Prader-Willi GSE117283.CTCF.hiPSC_Prader-Willi 160 bp overlap

ChIP hiPSC_failed-genome-editing GSE106870.CTCF.hiPSC_failed-genome-editing 201 bp overlap

ChIP hiPSC_parental-line GSE106870.CTCF.hiPSC_parental-line 188 bp overlap

ChIP keratinocyte GSE154221.CTCF.keratinocyte 655 bp overlap

ChIP leukemia GSE142161.CTCF.leukemia 179 bp overlap

ChIP leukemia_CEBPA-96h GSE142161.CTCF.leukemia_CEBPA-96h 245 bp overlap

ChIP neural_progenitor ENCSR125NBL.CTCF.neural_progenitor 204 bp overlap

ChIP osteocyte ENCFF929FPD 457 bp overlap

ChIP primary-glioblastoma_G523 GSE121601.CTCF.primary-glioblastoma_G523 161 bp overlap

ChIP right atrium auricular region ENCFF696NTN 505 bp overlap

ChIP right atrium auricular region ENCFF696NTN 489 bp overlap

ChIP sigmoid colon ENCFF397ZZF 485 bp overlap

CTCFL 1 dataset

Motif DE_24h DE_24h-CTCFL_MA1102.3 8 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF460KDD 284 bp overlap

Dmrt1 1 dataset

Motif DE_24h DE_24h-Dmrt1_MA1603.2 9 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 133 bp overlap

EGR1 3 datasets

Motif DE_24h DE_24h-EGR1_MA0162.5 10 bp overlap

ChIP GM12878 ENCSR000BMQ.EGR1.GM12878 97 bp overlap

ChIP Hep-G2 ENCSR026GSW.EGR1.Hep-G2 444 bp overlap

Motif DE_24h DE_24h-EGR3_MA0732.2 11 bp overlap

ChIP GM12878 ENCSR000BMB.ELF1.GM12878 260 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 552 bp overlap

EP300 2 datasets

ChIP WA01 ENCSR000BKK.EP300.WA01 169 bp overlap

ChIP WA01 ENCSR000AUQ.EP300.WA01 136 bp overlap

ESR1 12 datasets

ChIP MCF-7 GSE119057.ESR1.MCF-7 147 bp overlap

ChIP MCF-7_ARID1A-KO_4-OHT GSE123284.ESR1.MCF-7_ARID1A-KO_4-OHT 223 bp overlap

ChIP MCF-7_E2 GSE117941.ESR1.MCF-7_E2 327 bp overlap

ChIP MCF-7_E2 ERP000209.ESR1.MCF-7_E2 124 bp overlap

ChIP MCF-7_E2 GSE108883.ESR1.MCF-7_E2 182 bp overlap

ChIP MCF-7_ER_t50 GSE119057.ESR1.MCF-7_ER_t50 169 bp overlap

ChIP MCF-7_SHCRT_E2 ERP000380.ESR1.MCF-7_SHCRT_E2 123 bp overlap

ChIP MCF-7_SHCTR_E2_TNF GSE59530.ESR1.MCF-7_SHCTR_E2_TNF 180 bp overlap

ChIP MCF-7_estradiol-Dex_4h GSE99626.ESR1.MCF-7_estradiol-Dex_4h 167 bp overlap

ChIP MCF-7_estradiol_4h GSE99626.ESR1.MCF-7_estradiol_4h 211 bp overlap

ChIP T-47D_Y537S_E2 GSE148277.ESR1.T-47D_Y537S_E2 291 bp overlap

ChIP T-47D_siCont-IL6 GSE126004.ESR1.T-47D_siCont-IL6 276 bp overlap

ETS1 4 datasets

ChIP cardiomyocyte_D0 GSE129986.ETS1.cardiomyocyte_D0 517 bp overlap

ChIP cardiomyocyte_D2 GSE129986.ETS1.cardiomyocyte_D2 715 bp overlap

ChIP cardiomyocyte_D5 GSE129986.ETS1.cardiomyocyte_D5 249 bp overlap

ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 230 bp overlap

ChIP SU-DHL-5 GSE45982.EZH2.SU-DHL-5 103 bp overlap

FIGLA 1 dataset

Motif DE_24h DE_24h-FIGLA_MA0820.2 6 bp overlap

FOXA1 2 datasets

Motif DE_24h DE_24h-FOXA1_MA0148.5 8 bp overlap

ChIP LS180 GSE140533.FOXA1.LS180 61 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 446 bp overlap

ChIP DE DE-FOXA2-2 486 bp overlap

Motif DE_24h DE_24h-FOXA2_MA0047.4 8 bp overlap

FOXA3 1 dataset

Motif DE_24h DE_24h-FOXA3_MA1683.2 7 bp overlap

FOXC1 1 dataset

Motif DE_24h DE_24h-FOXC1_MA0032.2 11 bp overlap

FOXC2 1 dataset

Motif DE_24h DE_24h-FOXC2_MA0846.2 11 bp overlap

FOXD1 1 dataset

Motif DE_24h DE_24h-FOXD1_MA0031.2 7 bp overlap

FOXD2 1 dataset

Motif DE_24h DE_24h-FOXD2_MA0847.4 11 bp overlap

FOXF2 1 dataset

Motif DE_24h DE_24h-FOXF2_MA0030.2 9 bp overlap

FOXG1 1 dataset

Motif DE_24h DE_24h-FOXG1_MA0613.1 8 bp overlap

FOXH1 1 dataset

Motif DE_24h DE_24h-FOXH1_MA0479.2 8 bp overlap

FOXI1 1 dataset

Motif DE_24h DE_24h-FOXI1_MA0042.2 7 bp overlap

FOXK1 2 datasets

Motif DE_24h DE_24h-FOXK1_MA0852.3 7 bp overlap

ChIP WTC11 ENCFF875IGU 391 bp overlap

FOXK2 1 dataset

Motif DE_24h DE_24h-FOXK2_MA1103.3 7 bp overlap

FOXL1 1 dataset

Motif DE_24h DE_24h-FOXL1_MA0033.2 7 bp overlap

FOXN3 1 dataset

Motif DE_24h DE_24h-FOXN3_MA1489.1 8 bp overlap

FOXO4 1 dataset

Motif DE_24h DE_24h-FOXO4_MA0848.1 7 bp overlap

FOXO6 1 dataset

Motif DE_24h DE_24h-FOXO6_MA0849.1 7 bp overlap

FOXP1 2 datasets

Motif DE_24h DE_24h-FOXP1_MA0481.4 7 bp overlap

ChIP H9 GSE31006.FOXP1.H9 183 bp overlap

FOXP2 2 datasets

Motif DE_24h DE_24h-FOXP2_MA0593.2 9 bp overlap

Motif DE_24h DE_24h-FOXP2_MA0593.2 9 bp overlap

FOXP3 1 dataset

Motif DE_24h DE_24h-FOXP3_MA0850.1 7 bp overlap

FOXP4 2 datasets

Motif DE_24h DE_24h-FOXP4_MA2117.1 7 bp overlap

ChIP WTC11 ENCFF708TAF 377 bp overlap

FOXS1 1 dataset

Motif DE_24h DE_24h-FOXS1_MA2118.1 8 bp overlap

Foxf1 1 dataset

Motif DE_24h DE_24h-Foxf1_MA1606.2 7 bp overlap

Foxj2 1 dataset

Motif DE_24h DE_24h-Foxj2_MA0614.1 8 bp overlap

Foxj3 1 dataset

Motif DE_24h DE_24h-Foxj3_MA0851.2 9 bp overlap

Foxl2 1 dataset

Motif DE_24h DE_24h-Foxl2_MA1607.2 10 bp overlap

Foxn1 1 dataset

Motif DE_24h DE_24h-Foxn1_MA1684.1 6 bp overlap

Foxo1 1 dataset

Motif DE_24h DE_24h-Foxo1_MA0480.3 7 bp overlap

Foxo3 1 dataset

Motif DE_24h DE_24h-Foxo3_MA0157.4 7 bp overlap

GATA4 1 dataset

ChIP DE DE-GATA4-1 290 bp overlap

GATA6 8 datasets

ChIP DE DE-GATA6-1 301 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 403 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 594 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 589 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 576 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 581 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 610 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 305 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 553 bp overlap

GTF3C2 1 dataset

ChIP H9 GSE94418.GTF3C2.H9 79 bp overlap

Gfi1B 1 dataset

Motif DE_24h DE_24h-Gfi1B_MA0483.2 10 bp overlap

Motif DE_24h DE_24h-Gli1_MA1990.2 10 bp overlap

HDAC2 2 datasets

ChIP WA01 ENCSR000AVB.HDAC2.WA01 53 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 217 bp overlap

Motif DE_24h DE_24h-HES2_MA0616.3 9 bp overlap

Motif DE_24h DE_24h-HES6_MA1493.1 10 bp overlap

Motif DE_24h DE_24h-HEY1_MA0823.1 10 bp overlap

Motif DE_24h DE_24h-HEY2_MA0649.2 9 bp overlap

Motif DE_24h DE_24h-HIC2_MA0738.2 6 bp overlap

HIF1A 1 dataset

Motif DE_24h DE_24h-HIF1A_MA1106.2 6 bp overlap

HNRNPK 1 dataset

ChIP Hep-G2 GSE120104.HNRNPK.Hep-G2 316 bp overlap

Motif DE_24h DE_24h-Hic1_MA0739.2 8 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 386 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 163 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 317 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 554 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 303 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 603 bp overlap

KDM5B 1 dataset

ChIP Hep-G2 ENCSR227MRE.KDM5B.Hep-G2 180 bp overlap

KLF1 4 datasets

Motif DE_24h DE_24h-KLF1_MA0493.3 8 bp overlap

Motif DE_24h DE_24h-KLF1_MA0493.3 8 bp overlap

Motif DE_24h DE_24h-KLF1_MA0493.3 8 bp overlap

ChIP HEK293 ENCSR859BMR.KLF1.HEK293 210 bp overlap

KLF10 1 dataset

Motif DE_24h DE_24h-KLF10_MA1511.2 9 bp overlap

KLF11 1 dataset

Motif DE_24h DE_24h-KLF11_MA1512.2 10 bp overlap

KLF12 1 dataset

Motif DE_24h DE_24h-KLF12_MA0742.2 9 bp overlap

KLF14 1 dataset

Motif DE_24h DE_24h-KLF14_MA0740.2 9 bp overlap

KLF16 1 dataset

Motif DE_24h DE_24h-KLF16_MA0741.1 11 bp overlap

KLF17 1 dataset

Motif DE_24h DE_24h-KLF17_MA1514.2 14 bp overlap

KLF2 3 datasets

Motif DE_24h DE_24h-KLF2_MA1515.2 8 bp overlap

Motif DE_24h DE_24h-KLF2_MA1515.2 8 bp overlap

Motif DE_24h DE_24h-KLF2_MA1515.2 8 bp overlap

KLF4 4 datasets

Motif DE_24h DE_24h-KLF4_MA0039.5 8 bp overlap

Motif DE_24h DE_24h-KLF4_MA0039.5 8 bp overlap

Motif DE_24h DE_24h-KLF4_MA0039.5 8 bp overlap

Motif DE_24h DE_24h-KLF4_MA0039.5 8 bp overlap

KLF5 3 datasets

Motif DE_24h DE_24h-KLF5_MA0599.1 10 bp overlap

Motif DE_24h DE_24h-KLF5_MA0599.1 10 bp overlap

Motif DE_24h DE_24h-KLF5_MA0599.1 10 bp overlap

Motif DE_24h DE_24h-KLF7_MA1959.2 8 bp overlap

Motif DE_24h DE_24h-KLF9_MA1107.3 11 bp overlap

L3MBTL2 1 dataset

ChIP K-562 ENCSR530XQI.L3MBTL2.K-562 314 bp overlap

Motif DE_24h DE_24h-MAF_MA1520.2 13 bp overlap

Motif DE_24h DE_24h-MAFA_MA1521.2 13 bp overlap

Motif DE_24h DE_24h-MAX_MA0058.4 6 bp overlap

Motif DE_24h DE_24h-MAZ_MA1522.2 8 bp overlap

Motif DE_24h DE_24h-MAZ_MA1522.2 8 bp overlap

Motif DE_24h DE_24h-MAZ_MA1522.2 8 bp overlap

ChIP hESC_PRIMED GSE69646.MED1.hESC_PRIMED 657 bp overlap

MEIS1 1 dataset

Motif DE_24h DE_24h-MEIS1_MA0498.3 5 bp overlap

MLXIPL 1 dataset

Motif DE_24h DE_24h-MLXIPL_MA0664.2 8 bp overlap

Motif DE_24h DE_24h-MNT_MA0825.2 6 bp overlap

Motif DE_24h DE_24h-MSC_MA0665.1 10 bp overlap

MTA3 2 datasets

ChIP K-562 ENCSR180NCY.MTA3.K-562 259 bp overlap

ChIP K-562 ENCSR914NEI.MTA3.K-562 230 bp overlap

Motif DE_24h DE_24h-MYC_MA0147.4 8 bp overlap

Motif DE_24h DE_24h-MYF6_MA0667.1 10 bp overlap

MYOD1 1 dataset

Motif DE_24h DE_24h-MYOD1_MA0499.3 9 bp overlap

Mlxip 1 dataset

Motif DE_24h DE_24h-Mlxip_MA0622.2 6 bp overlap

NANOG 2 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 356 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 467 bp overlap

Motif DE_24h DE_24h-NFIB_MA1643.2 17 bp overlap

NIPBL 1 dataset

ChIP WA09_heat-shock GSE105028.NIPBL.WA09_heat-shock 326 bp overlap

NR2C2 1 dataset

Motif DE_24h DE_24h-NR2C2_MA0504.2 14 bp overlap

NR2F1 1 dataset

Motif DE_24h DE_24h-NR2F1_MA0017.3 12 bp overlap

NR3C1 1 dataset

ChIP MCF-7_E2_Dex GSE81510.NR3C1.MCF-7_E2_Dex 181 bp overlap

Npas2 1 dataset

Motif DE_24h DE_24h-Npas2_MA0626.2 8 bp overlap

Nr5A2 1 dataset

Motif DE_24h DE_24h-Nr5A2_MA0505.3 9 bp overlap

PATZ1 3 datasets

Motif DE_24h DE_24h-PATZ1_MA1961.2 11 bp overlap

Motif DE_24h DE_24h-PATZ1_MA1961.2 11 bp overlap

ChIP HepG2 ENCFF723PFC 151 bp overlap

Motif DE_24h DE_24h-PBX3_MA1114.2 11 bp overlap

PCBP1 2 datasets

ChIP Hep-G2 GSE120104.PCBP1.Hep-G2 261 bp overlap

ChIP Hep-G2 ENCSR872EVQ.PCBP1.Hep-G2 233 bp overlap

PCGF1 1 dataset

ChIP WA01 GSE104690.PCGF1.WA01 251 bp overlap

PDX1 3 datasets

ChIP hiPSC GSE125768.PDX1.hiPSC 258 bp overlap

ChIP hiPSC_derived_PPs GSE106949.PDX1.hiPSC_derived_PPs 226 bp overlap

ChIP islet ERP001456.PDX1.islet 137 bp overlap

PKNOX1 1 dataset

Motif DE_24h DE_24h-PKNOX1_MA0782.3 10 bp overlap

PLAG1 4 datasets

Motif DE_24h DE_24h-PLAG1_MA0163.1 14 bp overlap

Motif DE_24h DE_24h-PLAG1_MA0163.1 14 bp overlap

Motif DE_24h DE_24h-PLAG1_MA0163.1 14 bp overlap

Motif DE_24h DE_24h-PLAG1_MA0163.1 14 bp overlap

PLAGL2 2 datasets

Motif DE_24h DE_24h-PLAGL2_MA1548.2 8 bp overlap

Motif DE_24h DE_24h-PLAGL2_MA1548.2 8 bp overlap

POLR2A 1 dataset

ChIP upper lobe of left lung ENCFF095BJW 371 bp overlap

POU4F2 1 dataset

ChIP HNPC_DIF GSE74814.POU4F2.HNPC_DIF 170 bp overlap

POU5F1 6 datasets

ChIP BG03 GSE21614.POU5F1.BG03 155 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 715 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 267 bp overlap

ChIP NCCIT_SNF5 GSE36134.POU5F1.NCCIT_SNF5 400 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 339 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 186 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 702 bp overlap

PRDM9 2 datasets

Motif DE_24h DE_24h-PRDM9_MA1723.2 20 bp overlap

Motif DE_24h DE_24h-PRDM9_MA1723.2 20 bp overlap

Pou5f1::Sox2 1 dataset

Motif DE_24h DE_24h-Pou5f1Sox2_MA0142.1 15 bp overlap

Ptf1A 1 dataset

Motif DE_24h DE_24h-Ptf1A_MA1620.2 8 bp overlap

RAD21 22 datasets

ChIP GM12878 ENCFF101UQZ 191 bp overlap

ChIP GM12878 ENCSR000BMY.RAD21.GM12878 307 bp overlap

ChIP H1 ENCFF698EWO 241 bp overlap

ChIP H1 ENCFF967OJF 245 bp overlap

ChIP HCT-116 GSE131606.RAD21.HCT-116 94 bp overlap

ChIP HCT-116 GSE121355.RAD21.HCT-116 402 bp overlap

ChIP HCT-116 ENCSR000BSB.RAD21.HCT-116 158 bp overlap

ChIP HCT-116 GSE131606.RAD21.HCT-116 205 bp overlap

ChIP HCT-116_RAD21-mAC GSE104888.RAD21.HCT-116_RAD21-mAC 268 bp overlap

ChIP HCT116 ENCFF568PEO 311 bp overlap

ChIP HUVEC-C_hypoxia GSE94872.RAD21.HUVEC-C_hypoxia 144 bp overlap

ChIP Hep-G2 ENCSR054FKH.RAD21.Hep-G2 246 bp overlap

ChIP Hep-G2 ENCSR000EEG.RAD21.Hep-G2 184 bp overlap

ChIP HepG2 ENCFF360ZSW 217 bp overlap

ChIP HepG2 ENCFF906QIS 225 bp overlap

ChIP MCF-7 ENCSR000BTQ.RAD21.MCF-7 120 bp overlap

ChIP WA09 GSE105028.RAD21.WA09 219 bp overlap

ChIP WA09_heat-shock GSE105028.RAD21.WA09_heat-shock 320 bp overlap

ChIP hiPSC_CVI GSE106870.RAD21.hiPSC_CVI 143 bp overlap

ChIP hiPSC_IV8 GSE106870.RAD21.hiPSC_IV8 251 bp overlap

ChIP hiPSC_parental-line GSE106870.RAD21.hiPSC_parental-line 157 bp overlap

ChIP liver ENCFF522JHE 401 bp overlap

RARA::RXRA 1 dataset

Motif DE_24h DE_24h-RARARXRA_MA0159.1 17 bp overlap

RBBP5 2 datasets

ChIP WA01 ENCSR000AQC.RBBP5.WA01 74 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 228 bp overlap

Motif DE_24h DE_24h-RBPJ_MA1116.2 6 bp overlap

REST 2 datasets

ChIP K-562 ENCSR137ZMQ.REST.K-562 258 bp overlap

ChIP K562 ENCFF688UKW 411 bp overlap

RREB1 2 datasets

Motif DE_24h DE_24h-RREB1_MA0073.2 19 bp overlap

Motif DE_24h DE_24h-RREB1_MA0073.2 19 bp overlap

RUNX1T1 1 dataset

ChIP Kasumi-1 GSE115115.RUNX1T1.Kasumi-1 200 bp overlap

RUNX2 1 dataset

Motif DE_24h DE_24h-RUNX2_MA0511.2 9 bp overlap

ChIP WA01 GSE104690.RYBP.WA01 201 bp overlap

Runx1 1 dataset

Motif DE_24h DE_24h-Runx1_MA0002.3 9 bp overlap

SCRT1 1 dataset

Motif DE_24h DE_24h-SCRT1_MA0743.3 10 bp overlap

SCRT2 1 dataset

Motif DE_24h DE_24h-SCRT2_MA0744.3 10 bp overlap

SIN3A 1 dataset

ChIP WA01 ENCSR000EBO.SIN3A.WA01 120 bp overlap

SMAD2 1 dataset

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 533 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 572 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 715 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 715 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 678 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 715 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 703 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 673 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 607 bp overlap

SMAD3 5 datasets

ChIP BG03_DIFF_0H GSE36578.SMAD3.BG03_DIFF_0H 308 bp overlap

ChIP BG03_DIFF_2H GSE36578.SMAD3.BG03_DIFF_2H 275 bp overlap

ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 346 bp overlap

ChIP H69_4TGF GSE145250.SMAD3.H69_4TGF 253 bp overlap

ChIP hESC GSE29422.SMAD3.hESC 152 bp overlap

SMAD4 1 dataset

ChIP hESC GSE29422.SMAD4.hESC 179 bp overlap

SMARCA4 4 datasets

ChIP HS-SY-2_HA-tagged GSE108926.SMARCA4.HS-SY-2_HA-tagged 429 bp overlap

ChIP WA09_heat-shock GSE105028.SMARCA4.WA09_heat-shock 290 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 606 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 624 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 523 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 516 bp overlap

SMARCC1 3 datasets

ChIP DE_D1 S15-DE-d1-BAF155-exp1 368 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 586 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 612 bp overlap

SMC1 4 datasets

ChIP DKO GSE131606.SMC1.DKO 377 bp overlap

ChIP HCAEC GSE101921.SMC1.HCAEC 317 bp overlap

ChIP HCT-116 GSE131606.SMC1.HCT-116 264 bp overlap

ChIP monocyte_IFNg-LPS GSE120943.SMC1.monocyte_IFNg-LPS 169 bp overlap

SMC1A 1 dataset

ChIP Hep-G2 GSE76893.SMC1A.Hep-G2 363 bp overlap

SMC3 2 datasets

ChIP Hep-G2 ENCSR000EDW.SMC3.Hep-G2 132 bp overlap

ChIP hESC_D0 GSE116862.SMC3.hESC_D0 370 bp overlap

SNAI2 1 dataset

Motif DE_24h DE_24h-SNAI2_MA0745.3 8 bp overlap

SNAI3 1 dataset

Motif DE_24h DE_24h-SNAI3_MA1559.2 9 bp overlap

SOHLH2 1 dataset

Motif DE_24h DE_24h-SOHLH2_MA1560.2 8 bp overlap

SOX10 1 dataset

Motif DE_24h DE_24h-SOX10_MA0442.3 6 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 661 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 309 bp overlap

Motif DE_24h DE_24h-SP1_MA0079.5 9 bp overlap

Motif DE_24h DE_24h-SP1_MA0079.5 9 bp overlap

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 193 bp overlap

Motif DE_24h DE_24h-SP2_MA0516.3 9 bp overlap

Motif DE_24h DE_24h-SP4_MA0685.2 9 bp overlap

Motif DE_24h DE_24h-SP4_MA0685.2 9 bp overlap

Motif DE_24h DE_24h-SP4_MA0685.2 9 bp overlap

Motif DE_24h DE_24h-SP5_MA1965.2 6 bp overlap

Motif DE_24h DE_24h-SP5_MA1965.2 6 bp overlap

Motif DE_24h DE_24h-SP8_MA0747.2 11 bp overlap

Motif DE_24h DE_24h-SP9_MA1564.2 10 bp overlap

SREBF1 1 dataset

Motif DE_24h DE_24h-SREBF1_MA0595.1 10 bp overlap

SREBF2 1 dataset

Motif DE_24h DE_24h-SREBF2_MA0596.1 10 bp overlap

SRSF1 1 dataset

ChIP Hep-G2 GSE120104.SRSF1.Hep-G2 189 bp overlap

STAG1 4 datasets

ChIP Hep-G2 ENCSR167MTG.STAG1.Hep-G2 358 bp overlap

ChIP Hep-G2 ERP000209.STAG1.Hep-G2 139 bp overlap

ChIP HepG2 ENCFF843EBZ 301 bp overlap

ChIP erythroid GSE67783.STAG1.erythroid 198 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 259 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 303 bp overlap

TAL1::TCF3 1 dataset

Motif DE_24h DE_24h-TAL1TCF3_MA0091.2 10 bp overlap

TCF12 2 datasets

ChIP WA01 ENCSR000BIT.TCF12.WA01 92 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 166 bp overlap

TCF3 2 datasets

Motif DE_24h DE_24h-TCF3_MA0522.4 7 bp overlap

ChIP Kasumi-1 GSE43834.TCF3.Kasumi-1 164 bp overlap

TFAP2A 3 datasets

Motif DE_24h DE_24h-TFAP2A_MA0810.2 11 bp overlap

ChIP WA09 GSE105081.TFAP2A.WA09 159 bp overlap

ChIP WA09 GSE105081.TFAP2A.WA09 193 bp overlap

TFAP2B 1 dataset

Motif DE_24h DE_24h-TFAP2B_MA0811.2 11 bp overlap

TFAP2C 4 datasets

Motif DE_24h DE_24h-TFAP2C_MA0524.3 11 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 629 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 599 bp overlap

ChIP WA09 GSE105081.TFAP2C.WA09 468 bp overlap

TFAP4 2 datasets

Motif DE_24h DE_24h-TFAP4_MA0691.1 10 bp overlap

Motif DE_24h DE_24h-TFAP4_MA1570.1 10 bp overlap

ChIP H9_ectoderm GSE142050.TP53.H9_ectoderm 389 bp overlap

TRIM28 1 dataset

ChIP hESC GSE115387.TRIM28.hESC 174 bp overlap

Motif DE_24h DE_24h-Tbx6_MA1567.3 9 bp overlap

Tcf21 1 dataset

Motif DE_24h DE_24h-Tcf21_MA0832.2 10 bp overlap

VEZF1 6 datasets

Motif DE_24h DE_24h-VEZF1_MA1578.2 6 bp overlap

Motif DE_24h DE_24h-VEZF1_MA1578.2 6 bp overlap

Motif DE_24h DE_24h-VEZF1_MA1578.2 6 bp overlap

Motif DE_24h DE_24h-VEZF1_MA1578.2 6 bp overlap

ChIP K-562 ENCSR189YMA.VEZF1.K-562 298 bp overlap

ChIP K562 ENCFF053XDV 535 bp overlap

ChIP Huh-7 GSE97411.YY1.Huh-7 437 bp overlap

ChIP NT2-D1 ENCSR000EXG.YY1.NT2-D1 110 bp overlap

ZBTB2 1 dataset

ChIP Hep-G2 GSE97661.ZBTB2.Hep-G2 128 bp overlap

ZBTB24 1 dataset

Motif DE_24h DE_24h-ZBTB24_MA2330.1 10 bp overlap

ZBTB7A 1 dataset

ChIP K-562 ENCSR000BME.ZBTB7A.K-562 102 bp overlap

Motif DE_24h DE_24h-ZEB1_MA0103.4 6 bp overlap

Motif DE_24h DE_24h-ZIC4_MA0751.2 14 bp overlap

ZNF143 4 datasets

ChIP FLP76_T4 GSE39263.ZNF143.FLP76_T4 184 bp overlap

ChIP Hep-G2 ENCSR080UEM.ZNF143.Hep-G2 185 bp overlap

ChIP WA01 ENCSR000EBW.ZNF143.WA01 112 bp overlap

ChIP WA09_heat-shock GSE105028.ZNF143.WA09_heat-shock 223 bp overlap

ZNF148 4 datasets

Motif DE_24h DE_24h-ZNF148_MA1653.2 10 bp overlap

Motif DE_24h DE_24h-ZNF148_MA1653.2 10 bp overlap

Motif DE_24h DE_24h-ZNF148_MA1653.2 10 bp overlap

Motif DE_24h DE_24h-ZNF148_MA1653.2 10 bp overlap

ZNF207 1 dataset

ChIP WA09 GSE118632.ZNF207.WA09 320 bp overlap

ZNF213 1 dataset

Motif DE_24h DE_24h-ZNF213_MA2121.1 12 bp overlap

ZNF24 1 dataset

Motif DE_24h DE_24h-ZNF24_MA1124.1 13 bp overlap

ZNF257 1 dataset

ChIP HEK293T GSE78099.ZNF257.HEK293T 52 bp overlap

ZNF263 1 dataset

ChIP K-562 ENCSR000EWN.ZNF263.K-562 247 bp overlap

ZNF281 2 datasets

Motif DE_24h DE_24h-ZNF281_MA1630.3 10 bp overlap

Motif DE_24h DE_24h-ZNF281_MA1630.3 10 bp overlap

ChIP K-562 ENCSR195QFV.ZNF3.K-562 153 bp overlap

ZNF317 1 dataset

Motif DE_24h DE_24h-ZNF317_MA1593.2 8 bp overlap

ZNF320 2 datasets

Motif DE_24h DE_24h-ZNF320_MA1976.2 20 bp overlap

Motif DE_24h DE_24h-ZNF320_MA1976.2 20 bp overlap

ZNF398 1 dataset

ChIP H9 GSE133630.ZNF398.H9 154 bp overlap

ZNF416 1 dataset

Motif DE_24h DE_24h-ZNF416_MA1979.2 10 bp overlap

ZNF423 1 dataset

ChIP WTC11 ENCFF574PBR 317 bp overlap

ZNF460 1 dataset

Motif DE_24h DE_24h-ZNF460_MA1596.1 16 bp overlap

ZNF677 1 dataset

Motif DE_24h DE_24h-ZNF677_MA2101.1 12 bp overlap

ZNF682 1 dataset

Motif DE_24h DE_24h-ZNF682_MA1599.2 11 bp overlap

ZNF684 1 dataset

Motif DE_24h DE_24h-ZNF684_MA1600.2 14 bp overlap

ZNF708 1 dataset

Motif DE_24h DE_24h-ZNF708_MA1730.2 9 bp overlap

ZNF740 4 datasets

Motif DE_24h DE_24h-ZNF740_MA0753.3 10 bp overlap

Motif DE_24h DE_24h-ZNF740_MA0753.3 10 bp overlap

Motif DE_24h DE_24h-ZNF740_MA0753.3 10 bp overlap

ChIP K562 ENCFF505NFV 474 bp overlap

ZNF770 1 dataset

Motif DE_24h DE_24h-ZNF770_MA2099.1 8 bp overlap

Motif DE_24h DE_24h-Zfx_MA0146.3 10 bp overlap

Motif DE_24h DE_24h-Zic2_MA1629.2 9 bp overlap