Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZBTB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:151,239,598–151,241,662 | 151.3 kb | Distal (>10kb) Multiome | 604 | |
| chr6:151,373,738–151,374,525 | 17.4 kb | Distal (>10kb) Multiome | 304 | |
| chr6:151,389,414–151,392,227 | 1.1 kb | Proximal (<10kb) Multiome | 1234 | |
| chr6:151,451,713–151,453,312 | 60.7 kb | Distal (>10kb) Multiome | 1109 | |
| chr6:151,456,653–151,457,328 | 65.5 kb | Distal (>10kb) Multiome | 65 | |
| chr6:151,493,661–151,494,985 | 102.6 kb | Distal (>10kb) Multiome | 691 | |
| chr6:151,589,007–151,590,183 | 198.2 kb | Distal (>10kb) Multiome | 147 | |
| chr6:151,646,686–151,647,288 | 255.4 kb | Distal (>10kb) Multiome | 84 | |
| chr6:151,647,848–151,649,022 | 256.8 kb | Distal (>10kb) Multiome | 205 | |
| chr6:151,683,003–151,684,338 | 292.1 kb | Distal (>10kb) Multiome | 214 |
Genomic view of the ZBTB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.