Enables microtubule binding activity. Involved in mitotic spindle assembly checkpoint signaling; nuclear chromosome segregation; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF207. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF207 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF207, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:32,120,048–32,120,809 | 229.7 kb | Distal (>10kb) Multiome | 65 | |
| chr17:32,127,304–32,127,868 | 222.6 kb | Distal (>10kb) Multiome | 369 | |
| chr17:32,142,020–32,143,266 | 207.7 kb | Distal (>10kb) Multiome | 737 | |
| chr17:32,265,505–32,266,972 | 84.5 kb | Distal (>10kb) Multiome | 354 | |
| chr17:32,341,667–32,342,507 | 8.1 kb | Proximal (<10kb) Multiome | 954 | |
| chr17:32,349,923–32,350,604 | 17 bp | At TSS Multiome | 814 | |
| chr17:32,443,864–32,445,143 | 94.3 kb | Distal (>10kb) Multiome | 867 | |
| chr17:32,483,367–32,483,985 | 133.6 kb | Distal (>10kb) Multiome | 306 | |
| chr17:32,486,205–32,487,756 | 136.6 kb | Distal (>10kb) Multiome | 682 | |
| chr17:32,518,898–32,520,031 | 169.3 kb | Distal (>10kb) Multiome | 385 |
Genomic view of the ZNF207 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.