The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for MAX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:64,823,107–64,823,713 | 279.1 kb | Distal (>10kb) Multiome | 316 | |
| chr14:64,879,129–64,880,883 | 222.1 kb | Distal (>10kb) Multiome | 485 | |
| chr14:64,914,197–64,914,885 | 188.1 kb | Distal (>10kb) Multiome | 741 | |
| chr14:64,971,572–64,972,862 | 130.2 kb | Distal (>10kb) Multiome | 360 | |
| chr14:64,986,666–64,987,558 | 115.5 kb | Distal (>10kb) Multiome | 890 | |
| chr14:65,079,469–65,080,344 | 22.6 kb | Distal (>10kb) Multiome | 80 | |
| chr14:65,101,709–65,103,353 | 149 bp | At TSS Multiome | 804 | |
| chr14:65,187,313–65,188,086 | 85.1 kb | Distal (>10kb) Multiome | 124 | |
| chr14:65,212,664–65,213,594 | 110.7 kb | Distal (>10kb) Multiome | 50 | |
| chr14:65,226,838–65,227,673 | 124.8 kb | Distal (>10kb) Multiome | 588 | |
| chr14:65,255,144–65,256,610 | 153.3 kb | Distal (>10kb) Multiome | 499 | |
| chr14:65,281,802–65,282,455 | 179.7 kb | Distal (>10kb) Multiome | 179 | |
| chr14:65,334,489–65,335,389 | 232.4 kb | Distal (>10kb) Multiome | 283 |
Genomic view of the MAX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.