This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for HDAC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HDAC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HDAC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:113,776,752–113,777,865 | 193.9 kb | Distal (>10kb) Multiome | 198 | |
| chr6:113,854,564–113,856,446 | 116.1 kb | Distal (>10kb) Multiome | 538 | |
| chr6:113,856,568–113,860,608 | 113.9 kb | Distal (>10kb) Multiome | 1105 | |
| chr6:113,969,821–113,972,040 | 1.0 kb | Proximal (<10kb) Multiome | 1107 | |
| chr6:113,981,030–113,981,269 | 9.9 kb | Proximal (<10kb) | 99 |
Genomic view of the HDAC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.