Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF682. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF682 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF682, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:19,775,960–19,777,126 | 262.9 kb | Distal (>10kb) Multiome | 738 | |
| chr19:19,860,773–19,861,447 | 178.3 kb | Distal (>10kb) Multiome | 112 | |
| chr19:19,865,643–19,866,347 | 173.6 kb | Distal (>10kb) Multiome | 685 | |
| chr19:19,866,439–19,867,170 | 172.5 kb | Distal (>10kb) Multiome | 306 | |
| chr19:19,900,670–19,901,891 | 138.6 kb | Distal (>10kb) Multiome | 405 | |
| chr19:20,038,984–20,039,716 | 35 bp | At TSS Multiome | 495 | |
| chr19:20,051,726–20,052,860 | 12.7 kb | Distal (>10kb) Multiome | 402 | |
| chr19:20,066,768–20,067,242 | 27.5 kb | Distal (>10kb) Multiome | 8 | |
| chr19:20,067,957–20,069,262 | 29.4 kb | Distal (>10kb) Multiome | 17 | |
| chr19:20,077,737–20,078,423 | 38.4 kb | Distal (>10kb) Multiome | 212 | |
| chr19:20,082,410–20,083,233 | 43.3 kb | Distal (>10kb) Multiome | 155 | |
| chr19:20,166,957–20,167,632 | 127.7 kb | Distal (>10kb) Multiome | 222 | |
| chr19:20,237,984–20,238,687 | 199.1 kb | Distal (>10kb) Multiome | 188 | |
| chr19:20,261,348–20,261,810 | 222.1 kb | Distal (>10kb) Multiome | 44 | |
| chr19:20,285,651–20,286,726 | 246.6 kb | Distal (>10kb) Multiome | 95 |
Genomic view of the ZNF682 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.