The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PATZ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PATZ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PATZ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:31,080,687–31,081,783 | 265.2 kb | Distal (>10kb) Multiome | 636 | |
| chr22:31,084,596–31,085,743 | 261.2 kb | Distal (>10kb) Multiome | 448 | |
| chr22:31,098,574–31,099,237 | 247.5 kb | Distal (>10kb) Multiome | 150 | |
| chr22:31,104,824–31,105,447 | 241.3 kb | Distal (>10kb) Multiome | 187 | |
| chr22:31,107,269–31,107,915 | 238.7 kb | Distal (>10kb) Multiome | 627 | |
| chr22:31,127,262–31,127,766 | 218.8 kb | Distal (>10kb) Multiome | 74 | |
| chr22:31,140,179–31,140,721 | 205.8 kb | Distal (>10kb) Multiome | 244 | |
| chr22:31,160,052–31,160,698 | 186.1 kb | Distal (>10kb) Multiome | 709 | |
| chr22:31,211,835–31,212,727 | 134.1 kb | Distal (>10kb) Multiome | 769 | |
| chr22:31,290,525–31,291,372 | 55.5 kb | Distal (>10kb) Multiome | 818 | |
| chr22:31,343,299–31,343,527 | 14 bp | At TSS | 247 | |
| chr22:31,345,143–31,347,910 | 271 bp | At TSS Multiome | 954 | |
| chr22:31,362,564–31,363,231 | 16.5 kb | Distal (>10kb) Multiome | 164 | |
| chr22:31,399,166–31,400,036 | 53.1 kb | Distal (>10kb) Multiome | 913 | |
| chr22:31,489,111–31,490,354 | 143.5 kb | Distal (>10kb) Multiome | 819 | |
| chr22:31,496,060–31,496,942 | 150.1 kb | Distal (>10kb) Multiome | 769 | |
| chr22:31,630,284–31,631,283 | 284.5 kb | Distal (>10kb) Multiome | 643 |
Genomic view of the PATZ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.