This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for EZH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EZH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EZH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:148,698,154–148,700,147 | 184.4 kb | Distal (>10kb) Multiome | 840 | |
| chr7:148,877,517–148,877,679 | 6.6 kb | Proximal (<10kb) | 28 | |
| chr7:148,883,285–148,885,276 | 71 bp | At TSS Multiome | 917 | |
| chr7:148,940,713–148,941,315 | 56.8 kb | Distal (>10kb) Multiome | 792 | |
| chr7:148,966,846–148,967,346 | 82.7 kb | Distal (>10kb) Multiome | 532 | |
| chr7:148,982,929–148,984,226 | 99.3 kb | Distal (>10kb) Multiome | 671 | |
| chr7:148,987,066–148,988,336 | 103.2 kb | Distal (>10kb) Multiome | 765 | |
| chr7:149,027,878–149,029,294 | 144.4 kb | Distal (>10kb) Multiome | 992 | |
| chr7:149,065,040–149,066,286 | 181.6 kb | Distal (>10kb) Multiome | 971 | |
| chr7:149,071,460–149,072,205 | 187.6 kb | Distal (>10kb) Multiome | 300 | |
| chr7:149,090,124–149,091,686 | 206.5 kb | Distal (>10kb) Multiome | 1010 | |
| chr7:149,125,518–149,127,217 | 242.0 kb | Distal (>10kb) Multiome | 1147 | |
| chr7:149,145,364–149,146,036 | 261.3 kb | Distal (>10kb) Multiome | 220 | |
| chr7:149,147,030–149,148,737 | 263.1 kb | Distal (>10kb) Multiome | 938 |
Genomic view of the EZH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.