Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF24. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF24 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF24, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:35,240,066–35,241,553 | 103.4 kb | Distal (>10kb) Multiome | 906 | |
| chr18:35,289,760–35,290,683 | 54.2 kb | Distal (>10kb) Multiome | 970 | |
| chr18:35,343,705–35,344,835 | 95 bp | At TSS Multiome | 916 | |
| chr18:35,376,423–35,377,702 | 32.8 kb | Distal (>10kb) Multiome | 673 | |
| chr18:35,488,095–35,488,748 | 144.2 kb | Distal (>10kb) Multiome | 82 | |
| chr18:35,496,979–35,498,336 | 153.4 kb | Distal (>10kb) Multiome | 1055 | |
| chr18:35,580,775–35,581,562 | 237.1 kb | Distal (>10kb) Multiome | 563 |
Genomic view of the ZNF24 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.