MLXIPL
MLX interacting protein like | CHREBP, MIO, MONDOB, WS-bHLH, bHLHd14, WBSCR14

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Member of: DE-3 DE-3.41
Biological processes 63 terms
DNA binding (GO:0003677)DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription activator activity (GO:0001216)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor binding (GO:0140297)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)anatomical structure morphogenesis (GO:0009653)carbohydrate response element binding (GO:0035538)chromatin (GO:0000785)chromatin (GO:0000785)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)energy homeostasis (GO:0097009)fatty acid homeostasis (GO:0055089)glucose homeostasis (GO:0042593)glucose homeostasis (GO:0042593)glucose homeostasis (GO:0042593)glucose mediated signaling pathway (GO:0010255)glucose mediated signaling pathway (GO:0010255)lipid biosynthetic process (GO:0008610)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of oxidative phosphorylation (GO:0090324)negative regulation of signal transduction by p53 class mediator (GO:1901797)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of cell population proliferation (GO:0008284)positive regulation of fatty acid biosynthetic process (GO:0045723)positive regulation of fatty acid biosynthetic process (GO:0045723)positive regulation of glycolytic process (GO:0045821)positive regulation of glycolytic process (GO:0045821)positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0035774)positive regulation of lipid biosynthetic process (GO:0046889)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription from RNA polymerase II promoter by glucose (GO:0000432)protein dimerization activity (GO:0046983)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)transcription regulator complex (GO:0005667)transcription regulator complex (GO:0005667)triglyceride homeostasis (GO:0070328)
Expression (TPM)
MLXIPL — as a Regulated Gene

TFs regulating MLXIPL 0 TFs

Transcription factors with Perturb-seq knockdown data for MLXIPL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MLXIPL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to MLXIPL

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MLXIPL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr7:73,324,142–73,324,594 300.2 kb Distal (>10kb) Multiome 226
chr7:73,423,745–73,424,470 200.4 kb Distal (>10kb) Multiome 298
chr7:73,433,411–73,434,685 190.8 kb Distal (>10kb) Multiome 614
chr7:73,521,449–73,522,945 102.1 kb Distal (>10kb) Multiome 977
chr7:73,556,852–73,558,145 67.2 kb Distal (>10kb) Multiome 1080
chr7:73,578,111–73,579,357 45.8 kb Distal (>10kb) Multiome 765
chr7:73,607,081–73,607,465 at TSS At TSS 310
chr7:73,612,552–73,613,365 11.6 kb Distal (>10kb) Multiome 733
chr7:73,622,785–73,623,555 1.4 kb Proximal (<10kb) Multiome 659
chr7:73,623,956–73,624,915 47 bp At TSS Multiome 652
chr7:73,647,765–73,648,318 23.5 kb Distal (>10kb) Multiome 506
chr7:73,667,449–73,668,409 43.2 kb Distal (>10kb) Multiome 678
chr7:73,682,807–73,684,039 59.0 kb Distal (>10kb) Multiome 803
chr7:73,703,674–73,704,431 79.5 kb Distal (>10kb) Multiome 226
chr7:73,719,255–73,720,191 95.1 kb Distal (>10kb) Multiome 478
chr7:73,734,760–73,735,432 110.4 kb Distal (>10kb) Multiome 592
chr7:73,738,048–73,739,612 114.4 kb Distal (>10kb) Multiome 949
chr7:73,741,460–73,743,811 118.6 kb Distal (>10kb) Multiome 604
chr7:73,769,598–73,771,029 145.9 kb Distal (>10kb) Multiome 496
chr7:73,831,659–73,832,518 207.8 kb Distal (>10kb) Multiome 447
chr7:73,841,730–73,843,136 218.0 kb Distal (>10kb) Multiome 575
chr7:73,885,944–73,886,823 261.8 kb Distal (>10kb) Multiome 480

Genome Browser

Genomic view of the MLXIPL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr7:73,314,142 – 73,896,823
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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