Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF554. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF554 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF554, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,540,631–2,541,164 | 278.9 kb | Distal (>10kb) Multiome | 646 | |
| chr19:2,578,493–2,579,701 | 240.4 kb | Distal (>10kb) Multiome | 763 | |
| chr19:2,581,128–2,581,843 | 238.5 kb | Distal (>10kb) Multiome | 206 | |
| chr19:2,588,132–2,588,925 | 231.5 kb | Distal (>10kb) Multiome | 436 | |
| chr19:2,598,968–2,599,665 | 220.6 kb | Distal (>10kb) Multiome | 683 | |
| chr19:2,602,339–2,602,846 | 217.3 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,611,021–2,611,484 | 208.6 kb | Distal (>10kb) Multiome | 611 | |
| chr19:2,702,249–2,703,088 | 117.1 kb | Distal (>10kb) Multiome | 421 | |
| chr19:2,720,222–2,721,513 | 98.8 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,739,625–2,740,374 | 79.8 kb | Distal (>10kb) Multiome | 1063 | |
| chr19:2,782,866–2,783,778 | 36.5 kb | Distal (>10kb) Multiome | 998 | |
| chr19:2,784,850–2,785,981 | 34.5 kb | Distal (>10kb) Multiome | 682 | |
| chr19:2,819,641–2,820,625 | 18 bp | At TSS Multiome | 826 | |
| chr19:2,840,664–2,842,136 | 21.5 kb | Distal (>10kb) Multiome | 903 | |
| chr19:2,900,564–2,901,033 | 81.0 kb | Distal (>10kb) Multiome | 686 | |
| chr19:2,944,631–2,945,468 | 125.2 kb | Distal (>10kb) Multiome | 891 | |
| chr19:2,950,070–2,951,291 | 130.9 kb | Distal (>10kb) Multiome | 962 | |
| chr19:2,976,688–2,977,848 | 157.5 kb | Distal (>10kb) Multiome | 715 | |
| chr19:2,983,511–2,984,586 | 164.2 kb | Distal (>10kb) Multiome | 523 | |
| chr19:3,024,668–3,025,742 | 205.3 kb | Distal (>10kb) Multiome | 159 | |
| chr19:3,035,442–3,037,057 | 216.5 kb | Distal (>10kb) Multiome | 947 | |
| chr19:3,041,823–3,042,438 | 222.4 kb | Distal (>10kb) Multiome | 173 | |
| chr19:3,045,731–3,048,029 | 226.1 kb | Distal (>10kb) Multiome | 612 | |
| chr19:3,062,260–3,062,861 | 242.7 kb | Distal (>10kb) Multiome | 369 | |
| chr19:3,093,786–3,095,227 | 274.3 kb | Distal (>10kb) Multiome | 515 | |
| chr19:3,095,637–3,096,163 | 276.1 kb | Distal (>10kb) Multiome | 256 |
Genomic view of the ZNF554 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.