This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for RUNX1T1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RUNX1T1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RUNX1T1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:92,071,291–92,071,975 | 24.0 kb | Distal (>10kb) Multiome | 207 | |
| chr8:92,086,093–92,086,448 | 8.8 kb | Proximal (<10kb) | 9 | |
| chr8:92,089,950–92,090,222 | 5.0 kb | Proximal (<10kb) | 58 | |
| chr8:92,090,955–92,091,163 | 4.1 kb | Proximal (<10kb) | 11 | |
| chr8:92,094,433–92,096,717 | 423 bp | At TSS Multiome | 551 | |
| chr8:92,098,755–92,098,910 | 3.5 kb | Proximal (<10kb) | 60 | |
| chr8:92,101,237–92,101,695 | 6.0 kb | Proximal (<10kb) | 138 | |
| chr8:92,101,801–92,102,372 | 6.5 kb | Proximal (<10kb) | 182 | |
| chr8:92,102,652–92,104,140 | 7.9 kb | Proximal (<10kb) Multiome | 463 | |
| chr8:92,131,510–92,132,642 | 36.3 kb | Distal (>10kb) Multiome | 156 | |
| chr8:92,146,581–92,147,618 | 51.3 kb | Distal (>10kb) Multiome | 76 | |
| chr8:92,148,238–92,149,315 | 53.2 kb | Distal (>10kb) Multiome | 243 | |
| chr8:92,964,845–92,966,509 | 870.2 kb | Distal (>10kb) Multiome HiCAR | 936 | |
| chr8:93,129,642–93,130,643 | 1034.5 kb | Distal (>10kb) Multiome HiCAR | 86 | |
| chr8:93,740,245–93,741,472 | 1645.4 kb | Distal (>10kb) Multiome HiCAR | 876 | |
| chr8:93,915,949–93,918,134 | 1821.1 kb | Distal (>10kb) Multiome HiCAR | 821 | |
| chr8:93,943,280–93,944,641 | 1848.4 kb | Distal (>10kb) Multiome HiCAR | 354 | |
| chr8:93,952,630–93,953,256 | 1857.4 kb | Distal (>10kb) Multiome HiCAR | 63 |
Genomic view of the RUNX1T1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.