This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FOXC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FOXC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FOXC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:1,311,391–1,313,983 | 298.0 kb | Distal (>10kb) Multiome | 903 | |
| chr6:1,381,488–1,382,145 | 228.0 kb | Distal (>10kb) Multiome | 456 | |
| chr6:1,389,074–1,391,268 | 220.3 kb | Distal (>10kb) Multiome | 365 | |
| chr6:1,523,949–1,524,556 | 85.8 kb | Distal (>10kb) Multiome | 361 | |
| chr6:1,595,602–1,596,723 | 13.7 kb | Distal (>10kb) Multiome | 325 | |
| chr6:1,596,826–1,597,922 | 12.5 kb | Distal (>10kb) Multiome | 307 | |
| chr6:1,604,125–1,605,503 | 5.4 kb | Proximal (<10kb) Multiome | 591 | |
| chr6:1,606,436–1,607,329 | 3.0 kb | Proximal (<10kb) Multiome | 251 | |
| chr6:1,607,558–1,608,252 | 2.0 kb | Proximal (<10kb) Multiome | 448 | |
| chr6:1,608,357–1,612,111 | 72 bp | At TSS Multiome | 614 | |
| chr6:1,613,539–1,615,618 | 4.0 kb | Proximal (<10kb) Multiome | 556 | |
| chr6:1,619,218–1,620,936 | 10.3 kb | Distal (>10kb) Multiome | 223 | |
| chr6:1,726,266–1,726,743 | 116.6 kb | Distal (>10kb) Multiome | 172 | |
| chr6:2,244,856–2,246,522 | 635.7 kb | Distal (>10kb) Multiome HiCAR | 1006 | |
| chr6:2,634,053–2,634,953 | 1024.6 kb | Distal (>10kb) Multiome HiCAR | 729 | |
| chr6:2,985,539–2,987,671 | 1376.1 kb | Distal (>10kb) Multiome HiCAR | 402 | |
| chr6:2,987,802–2,990,098 | 1379.9 kb | Distal (>10kb) Multiome HiCAR | 1173 |
Genomic view of the FOXC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.