PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008]
Transcription factors with Perturb-seq knockdown data for PCGF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCGF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCGF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:74,497,707–74,500,027 | 7.4 kb | Proximal (<10kb) | 553 | |
| chr2:74,502,724–74,504,160 | 3.3 kb | Proximal (<10kb) | 816 | |
| chr2:74,506,905–74,508,524 | at TSS | At TSS | 1063 | |
| chr2:74,513,054–74,513,467 | 5.6 kb | Proximal (<10kb) | 288 | |
| chr2:74,514,120–74,514,925 | 6.7 kb | Proximal (<10kb) | 220 | |
| chr2:74,515,477–74,516,725 | 8.1 kb | Proximal (<10kb) | 262 |
Genomic view of the PCGF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.