KLF7

KLF transcription factor 7 | UKLF

The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Member of: DE-4 Developmental clusters: GC6

Biological processes 27 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)axon guidance (GO:0007411)axonogenesis (GO:0007409)chromatin (GO:0000785)dendrite morphogenesis (GO:0048813)glucose homeostasis (GO:0042593)negative regulation of adipose tissue development (GO:1904178)negative regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061179)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of transcription by RNA polymerase II (GO:0045944)regulation of epidermal cell differentiation (GO:0045604)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating KLF7 0 TFs

Transcription factors with Perturb-seq knockdown data for KLF7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLF7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to KLF7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLF7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:206,954,806–206,955,846	211.5 kb	Distal (>10kb) Multiome	169
chr2:207,093,267–207,093,735	73.6 kb	Distal (>10kb) Multiome	65
chr2:207,122,810–207,124,383	43.2 kb	Distal (>10kb) Multiome	254
chr2:207,140,626–207,140,823	6.5 kb	Proximal (<10kb)	8
chr2:207,142,062–207,142,764	7.9 kb	Proximal (<10kb)	83
chr2:207,148,801–207,149,994	17.4 kb	Distal (>10kb) Multiome	202
chr2:207,155,781–207,156,334	9.7 kb	Proximal (<10kb)	36
chr2:207,163,642–207,163,838	2.2 kb	Proximal (<10kb)	214
chr2:207,164,974–207,167,487	556 bp	At TSS Multiome	862
chr2:207,201,001–207,201,673	34.6 kb	Distal (>10kb) Multiome	71
chr2:207,202,647–207,203,423	36.2 kb	Distal (>10kb) Multiome	138
chr2:207,226,642–207,227,725	60.4 kb	Distal (>10kb) Multiome	248
chr2:207,334,461–207,335,111	168.0 kb	Distal (>10kb) Multiome	312
chr2:207,408,155–207,408,852	241.7 kb	Distal (>10kb) Multiome	224
chr2:207,473,001–207,473,846	306.6 kb	Distal (>10kb) Multiome HiCAR	203

Genome Browser

Genomic view of the KLF7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.