This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GADD45B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GADD45B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GADD45B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,235,315–2,237,253 | 239.5 kb | Distal (>10kb) Multiome | 1119 | |
| chr19:2,269,007–2,271,589 | 206.7 kb | Distal (>10kb) Multiome | 983 | |
| chr19:2,273,467–2,274,136 | 202.3 kb | Distal (>10kb) Multiome | 825 | |
| chr19:2,327,828–2,329,150 | 147.5 kb | Distal (>10kb) Multiome | 759 | |
| chr19:2,426,254–2,428,729 | 48.4 kb | Distal (>10kb) Multiome | 1035 | |
| chr19:2,456,419–2,457,381 | 19.1 kb | Distal (>10kb) Multiome | 579 | |
| chr19:2,461,902–2,462,483 | 14.0 kb | Distal (>10kb) Multiome | 382 | |
| chr19:2,462,877–2,463,379 | 12.9 kb | Distal (>10kb) Multiome | 764 | |
| chr19:2,474,412–2,477,595 | 64 bp | At TSS Multiome | 1104 | |
| chr19:2,477,687–2,478,133 | 1.6 kb | Proximal (<10kb) | 154 | |
| chr19:2,478,328–2,479,798 | 2.2 kb | Proximal (<10kb) | 488 | |
| chr19:2,489,041–2,489,512 | 13.2 kb | Distal (>10kb) Multiome | 276 | |
| chr19:2,540,631–2,541,164 | 64.8 kb | Distal (>10kb) Multiome | 646 | |
| chr19:2,578,493–2,579,701 | 103.3 kb | Distal (>10kb) Multiome HiCAR | 763 | |
| chr19:2,581,128–2,581,843 | 105.3 kb | Distal (>10kb) Multiome HiCAR | 206 | |
| chr19:2,588,132–2,588,925 | 112.3 kb | Distal (>10kb) Multiome HiCAR | 436 | |
| chr19:2,598,968–2,599,665 | 123.2 kb | Distal (>10kb) Multiome | 683 | |
| chr19:2,611,021–2,611,484 | 135.2 kb | Distal (>10kb) Multiome HiCAR | 611 | |
| chr19:2,702,249–2,703,088 | 226.6 kb | Distal (>10kb) Multiome | 421 | |
| chr19:2,720,222–2,721,513 | 245.0 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,739,625–2,740,374 | 264.0 kb | Distal (>10kb) Multiome | 1063 |
Genomic view of the GADD45B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.