This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STAG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:136,747,210–136,747,511 | 4.9 kb | Proximal (<10kb) | 35 | |
| chr3:136,751,181–136,753,220 | 185 bp | At TSS Multiome | 1046 | |
| chr3:136,818,569–136,819,674 | 66.6 kb | Distal (>10kb) Multiome | 656 | |
| chr3:136,819,787–136,820,421 | 67.9 kb | Distal (>10kb) Multiome | 524 | |
| chr3:136,861,045–136,862,941 | 109.8 kb | Distal (>10kb) Multiome | 966 | |
| chr3:137,032,463–137,033,394 | 280.4 kb | Distal (>10kb) Multiome HiCAR | 351 |
Genomic view of the STAG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.