This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for LMNB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMNB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMNB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,163,561–2,164,587 | 293.1 kb | Distal (>10kb) Multiome | 750 | |
| chr19:2,235,315–2,237,253 | 220.3 kb | Distal (>10kb) Multiome | 1119 | |
| chr19:2,269,007–2,271,589 | 187.6 kb | Distal (>10kb) Multiome | 983 | |
| chr19:2,273,467–2,274,136 | 183.2 kb | Distal (>10kb) Multiome | 825 | |
| chr19:2,327,828–2,329,150 | 128.4 kb | Distal (>10kb) Multiome | 759 | |
| chr19:2,424,712–2,426,099 | 31.7 kb | Distal (>10kb) Multiome | 261 | |
| chr19:2,426,254–2,428,729 | 29.2 kb | Distal (>10kb) Multiome | 1035 | |
| chr19:2,456,419–2,457,381 | 53 bp | At TSS Multiome | 579 | |
| chr19:2,461,902–2,462,483 | 5.1 kb | Proximal (<10kb) Multiome | 382 | |
| chr19:2,462,877–2,463,379 | 6.3 kb | Proximal (<10kb) Multiome | 764 | |
| chr19:2,474,412–2,477,595 | 19.1 kb | Distal (>10kb) Multiome | 1104 | |
| chr19:2,478,328–2,479,798 | 22.4 kb | Distal (>10kb) Multiome | 488 | |
| chr19:2,489,041–2,489,512 | 32.3 kb | Distal (>10kb) Multiome | 276 | |
| chr19:2,540,631–2,541,164 | 84.0 kb | Distal (>10kb) Multiome | 646 | |
| chr19:2,578,493–2,579,701 | 122.5 kb | Distal (>10kb) Multiome | 763 | |
| chr19:2,581,128–2,581,843 | 124.4 kb | Distal (>10kb) Multiome | 206 | |
| chr19:2,588,132–2,588,925 | 131.5 kb | Distal (>10kb) Multiome | 436 | |
| chr19:2,598,968–2,599,665 | 142.3 kb | Distal (>10kb) Multiome | 683 | |
| chr19:2,602,339–2,602,846 | 145.6 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,611,021–2,611,484 | 154.3 kb | Distal (>10kb) Multiome HiCAR | 611 | |
| chr19:2,702,249–2,703,088 | 245.8 kb | Distal (>10kb) Multiome | 421 | |
| chr19:2,720,222–2,721,513 | 264.1 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,739,625–2,740,374 | 283.2 kb | Distal (>10kb) Multiome | 1063 |
Genomic view of the LMNB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.