Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LINGO3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINGO3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINGO3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,034,637–2,035,967 | 273.1 kb | Distal (>10kb) Multiome | 368 | |
| chr19:2,041,744–2,042,811 | 265.9 kb | Distal (>10kb) Multiome | 586 | |
| chr19:2,049,171–2,052,365 | 256.9 kb | Distal (>10kb) Multiome | 977 | |
| chr19:2,060,703–2,062,560 | 246.6 kb | Distal (>10kb) Multiome | 913 | |
| chr19:2,095,898–2,097,954 | 211.5 kb | Distal (>10kb) Multiome | 945 | |
| chr19:2,150,726–2,152,200 | 156.4 kb | Distal (>10kb) Multiome | 761 | |
| chr19:2,163,561–2,164,587 | 144.3 kb | Distal (>10kb) Multiome | 750 | |
| chr19:2,235,315–2,237,253 | 71.5 kb | Distal (>10kb) Multiome | 1119 | |
| chr19:2,269,007–2,271,589 | 38.8 kb | Distal (>10kb) Multiome | 983 | |
| chr19:2,273,467–2,274,136 | 34.4 kb | Distal (>10kb) Multiome | 825 | |
| chr19:2,308,128–2,308,340 | at TSS | At TSS | 117 | |
| chr19:2,327,828–2,329,150 | 20.4 kb | Distal (>10kb) Multiome | 759 | |
| chr19:2,424,712–2,426,099 | 117.1 kb | Distal (>10kb) Multiome | 261 | |
| chr19:2,426,254–2,428,729 | 119.6 kb | Distal (>10kb) Multiome | 1035 | |
| chr19:2,456,419–2,457,381 | 148.9 kb | Distal (>10kb) Multiome | 579 | |
| chr19:2,461,902–2,462,483 | 153.9 kb | Distal (>10kb) Multiome | 382 | |
| chr19:2,462,877–2,463,379 | 155.1 kb | Distal (>10kb) Multiome | 764 | |
| chr19:2,474,412–2,477,595 | 167.9 kb | Distal (>10kb) Multiome | 1104 | |
| chr19:2,478,328–2,479,798 | 171.2 kb | Distal (>10kb) Multiome | 488 | |
| chr19:2,489,041–2,489,512 | 181.1 kb | Distal (>10kb) Multiome | 276 | |
| chr19:2,540,631–2,541,164 | 232.8 kb | Distal (>10kb) Multiome | 646 | |
| chr19:2,578,493–2,579,701 | 271.3 kb | Distal (>10kb) Multiome | 763 | |
| chr19:2,581,128–2,581,843 | 273.2 kb | Distal (>10kb) Multiome | 206 | |
| chr19:2,588,132–2,588,925 | 280.3 kb | Distal (>10kb) Multiome | 436 | |
| chr19:2,598,968–2,599,665 | 291.1 kb | Distal (>10kb) Multiome | 683 | |
| chr19:2,602,339–2,602,846 | 294.4 kb | Distal (>10kb) Multiome | 233 |
Genomic view of the LINGO3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.