YY1

YY1 transcription factor | DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.28

Biological processes 80 terms

B cell differentiation (GO:0030183)DNA binding (GO:0003677)DNA binding (GO:0003677)DNA damage response (GO:0006974)DNA damage response (GO:0006974)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor binding (GO:0140297)DNA-binding transcription repressor activity (GO:0001217)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)Ino80 complex (GO:0031011)PcG protein complex (GO:0031519)PcG protein complex (GO:0031519)RNA binding (GO:0003723)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)SMAD binding (GO:0046332)cell development (GO:0048468)cellular response to UV (GO:0034644)cellular response to interleukin-1 (GO:0071347)chromatin (GO:0000785)chromatin (GO:0000785)chromatin binding (GO:0003682)chromatin remodeling (GO:0006338)chromatin silencing complex (GO:0005677)chromosome organization (GO:0051276)cis-regulatory region sequence-specific DNA binding (GO:0000987)cis-regulatory region sequence-specific DNA binding (GO:0000987)cis-regulatory region sequence-specific DNA binding (GO:0000987)double-strand break repair via homologous recombination (GO:0000724)fibrillar center (GO:0001650)four-way junction DNA binding (GO:0000400)immunoglobulin heavy chain V-D-J recombination (GO:0071707)lncRNA binding (GO:0106222)negative regulation of cell growth involved in cardiac muscle cell development (GO:0061052)negative regulation of gene expression (GO:0010629)negative regulation of interferon-beta production (GO:0032688)negative regulation of miRNA transcription (GO:1902894)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear body (GO:0016604)nuclear matrix (GO:0016363)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA repair (GO:0045739)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of telomere maintenance in response to DNA damage (GO:1904507)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)promoter-specific chromatin binding (GO:1990841)protein binding (GO:0005515)regulation of DNA repair (GO:0006282)regulation of DNA replication (GO:0006275)regulation of DNA strand elongation (GO:0060382)regulation of DNA-templated transcription (GO:0006355)regulation of cell cycle (GO:0051726)regulation of chromosome organization (GO:0033044)regulation of embryonic development (GO:0045995)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)response to UV-C (GO:0010225)response to UV-C (GO:0010225)response to prostaglandin F (GO:0034696)ribonucleoprotein complex (GO:1990904)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)spermatogenesis (GO:0007283)telomere maintenance (GO:0000723)transcription cis-regulatory region binding (GO:0000976)transcription regulator complex (GO:0005667)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating YY1 0 TFs

Transcription factors with Perturb-seq knockdown data for YY1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YY1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to YY1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YY1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:99,971,046–99,972,540	267.6 kb	Distal (>10kb) Multiome	614
chr14:100,108,167–100,108,638	130.7 kb	Distal (>10kb) Multiome	372
chr14:100,159,111–100,160,199	79.4 kb	Distal (>10kb) Multiome	345
chr14:100,192,488–100,193,700	46.1 kb	Distal (>10kb) Multiome	969
chr14:100,213,903–100,215,015	24.6 kb	Distal (>10kb) Multiome	857
chr14:100,221,397–100,222,394	17.3 kb	Distal (>10kb) Multiome HiCAR	448
chr14:100,237,942–100,240,742	425 bp	At TSS Multiome	894
chr14:100,246,872–100,247,072	7.7 kb	Proximal (<10kb)	238
chr14:100,284,345–100,286,145	46.3 kb	Distal (>10kb) Multiome	894
chr14:100,304,634–100,307,624	65.9 kb	Distal (>10kb) Multiome	725
chr14:100,318,097–100,318,705	79.3 kb	Distal (>10kb) Multiome	363
chr14:100,348,695–100,349,830	110.2 kb	Distal (>10kb) Multiome	195
chr14:100,371,470–100,372,320	132.9 kb	Distal (>10kb) Multiome	99
chr14:100,372,706–100,373,117	133.8 kb	Distal (>10kb) Multiome	79
chr14:100,375,470–100,376,763	137.2 kb	Distal (>10kb) Multiome	889
chr14:100,393,734–100,394,422	154.9 kb	Distal (>10kb) Multiome	66

Genome Browser

Genomic view of the YY1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.