The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for MYF6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYF6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYF6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:80,702,959–80,703,272 | 4.4 kb | Proximal (<10kb) | 126 | |
| chr12:80,707,848–80,709,099 | 214 bp | At TSS | 237 | |
| chr12:80,709,889–80,710,938 | 2.3 kb | Proximal (<10kb) | 125 | |
| chr12:80,712,852–80,713,287 | 5.2 kb | Proximal (<10kb) | 106 | |
| chr12:80,713,772–80,716,302 | 6.1 kb | Proximal (<10kb) | 186 | |
| chr12:80,716,665–80,717,548 | 9.0 kb | Proximal (<10kb) | 189 |
Genomic view of the MYF6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.