ELF1

E74 like ETS transcription factor 1

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

Member of: DE-2 DE-2.1

Biological processes 27 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cell differentiation (GO:0030154)chromatin (GO:0000785)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)

Expression (TPM)

TFs regulating ELF1 0 TFs

Transcription factors with Perturb-seq knockdown data for ELF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ELF1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr13:40,770,737–40,771,525	290.2 kb	Distal (>10kb) Multiome	1000
chr13:40,789,168–40,790,225	271.9 kb	Distal (>10kb) Multiome	837
chr13:40,921,270–40,922,017	139.8 kb	Distal (>10kb) Multiome	675
chr13:41,060,003–41,062,196	205 bp	At TSS Multiome	1139
chr13:41,085,849–41,086,392	24.7 kb	Distal (>10kb) Multiome	126
chr13:41,107,127–41,108,367	46.3 kb	Distal (>10kb) Multiome	291
chr13:41,132,141–41,133,085	71.4 kb	Distal (>10kb) Multiome	774
chr13:41,194,020–41,194,940	133.1 kb	Distal (>10kb) Multiome	837
chr13:41,263,241–41,263,968	202.2 kb	Distal (>10kb) Multiome	597
chr13:41,310,956–41,312,145	249.9 kb	Distal (>10kb) Multiome	855

Genome Browser

Genomic view of the ELF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.