SIN3A
SIN3 transcription regulator family member A | DKFZP434K2235, KIAA0700

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

Member of: DE-8 DE-8.8 Developmental clusters: GC1
Biological processes 58 terms
DNA binding (GO:0003677)RNA binding (GO:0003723)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)Sin3-type complex (GO:0070822)Sin3-type complex (GO:0070822)Sin3-type complex (GO:0070822)activation of innate immune response (GO:0002218)cellular response to dopamine (GO:1903351)cellular response to tert-butyl hydroperoxide (GO:0072736)cerebral cortex neuron differentiation (GO:0021895)cerebral cortex neuron differentiation (GO:0021895)chromatin (GO:0000785)chromatin (GO:0000785)chromatin binding (GO:0003682)chromosome (GO:0005694)heterochromatin formation (GO:0031507)histone deacetylase complex (GO:0000118)kinetochore (GO:0000776)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of cell migration (GO:0030336)negative regulation of circadian rhythm (GO:0042754)negative regulation of circadian rhythm (GO:0042754)negative regulation of protein localization to nucleus (GO:1900181)negative regulation of stem cell population maintenance (GO:1902455)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription initiation by RNA polymerase II (GO:0060633)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of defense response to virus by host (GO:0002230)positive regulation of neuron differentiation (GO:0045666)positive regulation of neuron differentiation (GO:0045666)positive regulation of stem cell population maintenance (GO:1902459)protein binding (GO:0005515)protein-containing complex (GO:0032991)protein-containing complex binding (GO:0044877)regulation of DNA-templated transcription (GO:0006355)regulation of axon extension (GO:0030516)regulation of axon extension (GO:0030516)regulation of hormone levels (GO:0010817)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)transcription regulator complex (GO:0005667)transcription regulator inhibitor activity (GO:0140416)transcription repressor complex (GO:0017053)type I interferon-mediated signaling pathway (GO:0060337)
Expression (TPM)
SIN3A — as a Regulated Gene

TFs regulating SIN3A 0 TFs

Transcription factors with Perturb-seq knockdown data for SIN3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIN3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SIN3A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIN3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr15:75,178,233–75,178,833 277.3 kb Distal (>10kb) Multiome 386
chr15:75,200,527–75,203,502 253.8 kb Distal (>10kb) Multiome 928
chr15:75,335,855–75,336,339 119.7 kb Distal (>10kb) Multiome 665
chr15:75,346,877–75,348,733 108.3 kb Distal (>10kb) Multiome 738
chr15:75,367,625–75,369,002 87.6 kb Distal (>10kb) Multiome 1121
chr15:75,450,273–75,456,388 107 bp At TSS Multiome 1174
chr15:75,579,138–75,580,015 123.7 kb Distal (>10kb) Multiome 683
chr15:75,624,816–75,626,356 170.0 kb Distal (>10kb) Multiome 987
chr15:75,639,562–75,640,798 184.6 kb Distal (>10kb) Multiome HiCAR 999
chr15:75,647,017–75,648,674 192.1 kb Distal (>10kb) Multiome HiCAR 795
chr15:75,672,794–75,673,400 217.2 kb Distal (>10kb) Multiome 226
chr15:75,712,716–75,713,248 257.1 kb Distal (>10kb) Multiome 318
chr15:75,738,177–75,739,332 283.0 kb Distal (>10kb) Multiome 611

Genome Browser

Genomic view of the SIN3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr15:75,168,233 – 75,749,332
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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