Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in membrane and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF708. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF708 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF708, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:19,532,119–19,532,674 | 1797.0 kb | Distal (>10kb) Multiome HiCAR | 405 | |
| chr19:19,538,087–19,538,726 | 1791.1 kb | Distal (>10kb) Multiome HiCAR | 255 | |
| chr19:19,775,960–19,777,126 | 1552.8 kb | Distal (>10kb) Multiome HiCAR | 738 | |
| chr19:20,237,984–20,238,687 | 1090.8 kb | Distal (>10kb) Multiome HiCAR | 188 | |
| chr19:21,081,742–21,082,659 | 247.2 kb | Distal (>10kb) Multiome | 412 | |
| chr19:21,141,765–21,142,544 | 187.4 kb | Distal (>10kb) Multiome | 378 | |
| chr19:21,328,454–21,328,648 | 733 bp | At TSS | 52 | |
| chr19:21,328,840–21,329,770 | 79 bp | At TSS Multiome | 544 | |
| chr19:21,358,710–21,359,820 | 29.6 kb | Distal (>10kb) Multiome | 326 | |
| chr19:21,396,727–21,397,616 | 67.7 kb | Distal (>10kb) Multiome | 498 | |
| chr19:21,835,386–21,836,775 | 506.8 kb | Distal (>10kb) Multiome HiCAR | 486 |
Genomic view of the ZNF708 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.