SREBF2

sterol regulatory element binding transcription factor 2 | SREBP2, bHLHd2

This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Member of: DE-2 Developmental clusters: GC1

Biological processes 63 terms

C-8 sterol isomerase activity (GO:0000247)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)E-box binding (GO:0070888)ER to Golgi transport vesicle membrane (GO:0012507)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)SREBP signaling pathway (GO:0032933)SREBP signaling pathway (GO:0032933)SREBP signaling pathway (GO:0032933)SREBP-SCAP-Insig complex (GO:0032937)cellular response to laminar fluid shear stress (GO:0071499)cellular response to low-density lipoprotein particle stimulus (GO:0071404)cellular response to starvation (GO:0009267)cholesterol metabolic process (GO:0008203)chromatin (GO:0000785)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)lipid metabolic process (GO:0006629)membrane (GO:0016020)negative regulation of amyloid-beta clearance (GO:1900222)negative regulation of cholesterol efflux (GO:0090370)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of cholesterol biosynthetic process (GO:0045542)positive regulation of cholesterol biosynthetic process (GO:0045542)positive regulation of cholesterol biosynthetic process (GO:0045542)positive regulation of cholesterol storage (GO:0010886)positive regulation of cholesterol storage (GO:0010886)positive regulation of miRNA transcription (GO:1902895)positive regulation of protein localization to mitochondrion (GO:1903749)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein dimerization activity (GO:0046983)regulation of Notch signaling pathway (GO:0008593)regulation of mitophagy (GO:1901524)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating SREBF2 0 TFs

Transcription factors with Perturb-seq knockdown data for SREBF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SREBF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SREBF2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SREBF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:41,543,855–41,544,782	288.5 kb	Distal (>10kb) Multiome	755
chr22:41,589,188–41,590,530	243.1 kb	Distal (>10kb) Multiome	758
chr22:41,620,173–41,622,049	212.0 kb	Distal (>10kb) Multiome	880
chr22:41,666,496–41,667,405	166.2 kb	Distal (>10kb) Multiome	725
chr22:41,697,169–41,697,792	135.7 kb	Distal (>10kb) Multiome	464
chr22:41,800,274–41,801,345	32.5 kb	Distal (>10kb) Multiome	816
chr22:41,832,291–41,834,215	197 bp	At TSS Multiome	1023
chr22:41,845,927–41,846,489	13.0 kb	Distal (>10kb) Multiome	271
chr22:41,909,821–41,910,788	77.2 kb	Distal (>10kb) Multiome	251
chr22:41,913,915–41,914,497	81.1 kb	Distal (>10kb) Multiome	143
chr22:41,914,624–41,915,454	82.0 kb	Distal (>10kb) Multiome	273
chr22:41,919,501–41,920,436	86.9 kb	Distal (>10kb) Multiome	337
chr22:41,926,076–41,926,820	93.2 kb	Distal (>10kb) Multiome	442
chr22:41,945,821–41,947,304	113.8 kb	Distal (>10kb) Multiome	896
chr22:41,957,553–41,958,332	124.8 kb	Distal (>10kb) Multiome	456
chr22:41,976,503–41,977,084	143.7 kb	Distal (>10kb) Multiome	294
chr22:42,070,303–42,071,253	237.7 kb	Distal (>10kb) Multiome	833
chr22:42,074,171–42,074,703	241.3 kb	Distal (>10kb) Multiome	178
chr22:42,079,194–42,080,293	246.7 kb	Distal (>10kb) Multiome	872
chr22:42,090,032–42,091,609	257.8 kb	Distal (>10kb) Multiome	910

Genome Browser

Genomic view of the SREBF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.