ZBTB7A
zinc finger and BTB domain containing 7A | DKFZp547O146, FBI-1, LRF, ZNF857A, pokemon, ZBTB7

Enables several functions, including SMAD binding activity; nuclear androgen receptor binding activity; and transcription corepressor binding activity. Involved in several processes, including erythrocyte maturation; negative regulation of signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 57 terms
B cell differentiation (GO:0030183)B cell differentiation (GO:0030183)DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor binding (GO:0140297)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-dependent protein kinase complex (GO:0070418)DNA-templated transcription (GO:0006351)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)SMAD binding (GO:0046332)SMAD binding (GO:0046332)chromatin organization (GO:0006325)chromatin organization (GO:0006325)chromatin remodeling (GO:0006338)cytoplasm (GO:0005737)double-strand break repair via classical nonhomologous end joining (GO:0097680)double-strand break repair via classical nonhomologous end joining (GO:0097680)erythrocyte maturation (GO:0043249)erythrocyte maturation (GO:0043249)erythrocyte maturation (GO:0043249)fat cell differentiation (GO:0045444)histone acetyltransferase binding (GO:0035035)histone acetyltransferase binding (GO:0035035)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of Notch signaling pathway (GO:0045746)negative regulation of Notch signaling pathway (GO:0045746)negative regulation of androgen receptor signaling pathway (GO:0060766)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)nuclear androgen receptor binding (GO:0050681)nuclear androgen receptor binding (GO:0050681)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein localization to nucleus (GO:0034504)regulation of alternative mRNA splicing, via spliceosome (GO:0000381)regulation of apoptotic process (GO:0042981)regulation of glycolytic process (GO:0006110)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription regulatory region DNA binding (GO:2000677)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)site of double-strand break (GO:0035861)site of double-strand break (GO:0035861)transcription corepressor binding (GO:0001222)transcription corepressor binding (GO:0001222)
Expression (TPM)
ZBTB7A — as a Regulated Gene

TFs regulating ZBTB7A 0 TFs

Transcription factors with Perturb-seq knockdown data for ZBTB7A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB7A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ZBTB7A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB7A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:3,786,012–3,786,456 280.7 kb Distal (>10kb) Multiome 237
chr19:3,868,451–3,869,181 197.9 kb Distal (>10kb) Multiome 233
chr19:3,932,937–3,933,664 133.6 kb Distal (>10kb) Multiome 198
chr19:3,968,623–3,969,280 98.1 kb Distal (>10kb) Multiome 547
chr19:3,970,535–3,971,713 95.7 kb Distal (>10kb) Multiome 728
chr19:3,985,032–3,985,862 81.4 kb Distal (>10kb) Multiome 932
chr19:3,987,682–3,988,217 78.9 kb Distal (>10kb) Multiome 346
chr19:4,006,992–4,008,553 59.3 kb Distal (>10kb) Multiome 888
chr19:4,064,058–4,067,782 986 bp At TSS Multiome 811
chr19:4,123,681–4,124,581 57.3 kb Distal (>10kb) Multiome 798
chr19:4,182,102–4,182,890 115.7 kb Distal (>10kb) Multiome 862
chr19:4,198,066–4,198,600 131.4 kb Distal (>10kb) Multiome 214
chr19:4,246,623–4,247,617 180.4 kb Distal (>10kb) Multiome 960
chr19:4,326,625–4,329,107 261.6 kb Distal (>10kb) Multiome 567
chr19:4,342,323–4,344,016 276.0 kb Distal (>10kb) Multiome 969

Genome Browser

Genomic view of the ZBTB7A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:3,776,012 – 4,354,016
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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