BRD4
bromodomain containing 4 | CAP, FSHRG4, HUNK1, HUNKI, MCAP

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Member of: DE-2
Biological processes 46 terms
DNA damage response (GO:0006974)P-TEFb complex binding (GO:0106140)RNA polymerase II C-terminal domain binding (GO:0099122)RNA polymerase II CTD heptapeptide repeat kinase activity (GO:0008353)chromatin (GO:0000785)chromatin binding (GO:0003682)chromatin binding (GO:0003682)chromatin remodeling (GO:0006338)chromatin remodeling (GO:0006338)chromosome (GO:0005694)chromosome (GO:0005694)condensed nuclear chromosome (GO:0000794)enzyme binding (GO:0019899)histone H3K27ac reader activity (GO:0140119)histone H3K9ac reader activity (GO:0140072)histone H4 reader activity (GO:0140008)histone H4K12ac reader activity (GO:0140011)histone H4K16ac reader activity (GO:0140046)histone H4K5ac reader activity (GO:0140012)histone H4K8ac reader activity (GO:0140055)histone binding (GO:0042393)host-mediated suppression of viral transcription (GO:0043922)negative regulation of DNA damage checkpoint (GO:2000002)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)p53 binding (GO:0002039)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)positive regulation of T-helper 17 cell lineage commitment (GO:2000330)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription elongation by RNA polymerase II (GO:0032968)positive regulation of transcription elongation by RNA polymerase II (GO:0032968)protein binding (GO:0005515)protein serine/threonine kinase activity (GO:0004674)protein-macromolecule adaptor activity (GO:0030674)regulation of DNA-templated transcription (GO:0006355)regulation of inflammatory response (GO:0050727)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)transcription cis-regulatory region binding (GO:0000976)transcription coactivator activity (GO:0003713)transcription coregulator activity (GO:0003712)
Expression (TPM)
BRD4 — as a Regulated Gene

TFs regulating BRD4 0 TFs

Transcription factors with Perturb-seq knockdown data for BRD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to BRD4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:15,073,077–15,073,718 258.5 kb Distal (>10kb) Multiome 204
chr19:15,106,942–15,107,576 224.6 kb Distal (>10kb) Multiome 339
chr19:15,113,323–15,113,828 218.3 kb Distal (>10kb) Multiome 116
chr19:15,124,546–15,126,107 206.2 kb Distal (>10kb) Multiome 949
chr19:15,177,520–15,178,026 154.2 kb Distal (>10kb) Multiome 499
chr19:15,180,886–15,181,623 150.7 kb Distal (>10kb) Multiome 355
chr19:15,195,187–15,196,375 135.8 kb Distal (>10kb) Multiome 408
chr19:15,199,629–15,201,437 131.8 kb Distal (>10kb) Multiome 398
chr19:15,222,727–15,224,168 108.4 kb Distal (>10kb) Multiome 521
chr19:15,231,632–15,233,858 98.7 kb Distal (>10kb) Multiome 414
chr19:15,324,741–15,325,392 7.0 kb Proximal (<10kb) Multiome 183
chr19:15,329,987–15,330,443 1.5 kb Proximal (<10kb) 115
chr19:15,331,471–15,332,992 631 bp At TSS Multiome 641
chr19:15,378,833–15,380,802 48.0 kb Distal (>10kb) Multiome 913
chr19:15,418,493–15,419,441 87.2 kb Distal (>10kb) Multiome 892
chr19:15,432,448–15,433,787 101.0 kb Distal (>10kb) Multiome 766
chr19:15,449,146–15,450,281 117.9 kb Distal (>10kb) Multiome 446
chr19:15,451,962–15,453,427 120.6 kb Distal (>10kb) Multiome 428
chr19:15,456,680–15,457,763 125.3 kb Distal (>10kb) Multiome 240
chr19:15,555,803–15,556,689 224.1 kb Distal (>10kb) Multiome 669
chr19:16,110,632–16,112,318 779.7 kb Distal (>10kb) Multiome HiCAR 866

Genome Browser

Genomic view of the BRD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:15,063,077 – 16,122,318
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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