This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:47,648,863–47,650,987 | 246.6 kb | Distal (>10kb) Multiome | 1152 | |
| chr17:47,693,705–47,695,210 | 201.8 kb | Distal (>10kb) Multiome | 619 | |
| chr17:47,733,002–47,733,810 | 163.0 kb | Distal (>10kb) Multiome | 366 | |
| chr17:47,789,633–47,790,336 | 106.2 kb | Distal (>10kb) Multiome | 395 | |
| chr17:47,831,256–47,831,955 | 64.7 kb | Distal (>10kb) Multiome HiCAR | 856 | |
| chr17:47,840,790–47,841,702 | 55.0 kb | Distal (>10kb) Multiome HiCAR | 833 | |
| chr17:47,847,253–47,848,429 | 48.5 kb | Distal (>10kb) Multiome HiCAR | 193 | |
| chr17:47,850,617–47,851,614 | 45.1 kb | Distal (>10kb) Multiome | 694 | |
| chr17:47,889,999–47,890,223 | 6.0 kb | Proximal (<10kb) | 442 | |
| chr17:47,895,361–47,896,955 | 119 bp | At TSS Multiome | 1031 | |
| chr17:47,902,020–47,902,508 | 5.9 kb | Proximal (<10kb) Multiome | 101 | |
| chr17:47,941,283–47,941,880 | 45.3 kb | Distal (>10kb) Multiome | 958 | |
| chr17:47,970,487–47,971,547 | 74.7 kb | Distal (>10kb) Multiome | 1061 | |
| chr17:48,023,351–48,024,470 | 127.3 kb | Distal (>10kb) Multiome | 591 | |
| chr17:48,024,599–48,025,777 | 129.0 kb | Distal (>10kb) Multiome | 759 | |
| chr17:48,026,284–48,026,933 | 130.4 kb | Distal (>10kb) Multiome | 543 | |
| chr17:48,047,576–48,049,198 | 152.0 kb | Distal (>10kb) Multiome | 1134 | |
| chr17:48,053,836–48,055,155 | 158.2 kb | Distal (>10kb) Multiome | 327 | |
| chr17:48,055,581–48,056,000 | 159.7 kb | Distal (>10kb) Multiome | 337 | |
| chr17:48,100,593–48,101,963 | 205.2 kb | Distal (>10kb) Multiome | 974 | |
| chr17:48,107,198–48,108,007 | 211.4 kb | Distal (>10kb) Multiome | 841 | |
| chr17:48,160,363–48,161,134 | 264.5 kb | Distal (>10kb) Multiome | 299 |
Genomic view of the SP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.