SGTA

small glutamine rich tetratricopeptide repeat co-chaperone alpha | SGT1, UBP, Vpu, alphaSGT, hSGT, SGT

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]

Member of: DE-6

Biological processes 23 terms

BAT3 complex binding (GO:1904288)ERAD pathway (GO:0036503)TRC complex (GO:0072380)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)identical protein binding (GO:0042802)identical protein binding (GO:0042802)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)molecular adaptor activity (GO:0060090)negative regulation of ERAD pathway (GO:1904293)negative regulation of ubiquitin-dependent protein catabolic process (GO:2000059)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of ERAD pathway (GO:1904294)positive regulation of ubiquitin-dependent protein catabolic process (GO:2000060)post-translational protein targeting to endoplasmic reticulum membrane (GO:0006620)protein binding (GO:0005515)tail-anchored membrane protein insertion into ER membrane (GO:0071816)

Expression (TPM)

TFs regulating SGTA 0 TFs

Transcription factors with Perturb-seq knockdown data for SGTA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SGTA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SGTA

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SGTA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:2,489,041–2,489,512	294.0 kb	Distal (>10kb) Multiome	276
chr19:2,540,631–2,541,164	242.3 kb	Distal (>10kb) Multiome	646
chr19:2,578,493–2,579,701	203.8 kb	Distal (>10kb) Multiome	763
chr19:2,581,128–2,581,843	201.9 kb	Distal (>10kb) Multiome	206
chr19:2,588,132–2,588,925	194.9 kb	Distal (>10kb) Multiome	436
chr19:2,598,968–2,599,665	184.0 kb	Distal (>10kb) Multiome	683
chr19:2,602,339–2,602,846	180.7 kb	Distal (>10kb) Multiome	233
chr19:2,611,021–2,611,484	172.0 kb	Distal (>10kb) Multiome	611
chr19:2,702,249–2,703,088	80.5 kb	Distal (>10kb) Multiome	421
chr19:2,720,222–2,721,513	62.2 kb	Distal (>10kb) Multiome	233
chr19:2,739,625–2,740,374	43.2 kb	Distal (>10kb) Multiome	1063
chr19:2,782,866–2,783,778	142 bp	At TSS Multiome	998
chr19:2,784,850–2,785,981	2.1 kb	Proximal (<10kb) Multiome	682
chr19:2,819,641–2,820,625	36.6 kb	Distal (>10kb) Multiome	826
chr19:2,840,664–2,842,136	58.1 kb	Distal (>10kb) Multiome	903
chr19:2,900,564–2,901,033	117.6 kb	Distal (>10kb) Multiome	686
chr19:2,944,631–2,945,468	161.8 kb	Distal (>10kb) Multiome	891
chr19:2,950,070–2,951,291	167.5 kb	Distal (>10kb) Multiome	962
chr19:2,976,688–2,977,848	194.1 kb	Distal (>10kb) Multiome	715
chr19:2,983,511–2,984,586	200.8 kb	Distal (>10kb) Multiome	523
chr19:3,024,668–3,025,742	241.9 kb	Distal (>10kb) Multiome	159
chr19:3,035,442–3,037,057	253.1 kb	Distal (>10kb) Multiome	947
chr19:3,041,823–3,042,438	259.0 kb	Distal (>10kb) Multiome	173
chr19:3,045,731–3,048,029	262.7 kb	Distal (>10kb) Multiome	612
chr19:3,062,260–3,062,861	279.3 kb	Distal (>10kb) Multiome	369
chr19:4,456,541–4,458,172	1674.5 kb	Distal (>10kb) Multiome HiCAR	757

Genome Browser

Genomic view of the SGTA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.