HIF1A

HIF1A

hypoxia inducible factor 1 subunit alpha | HIF-1alpha, HIF1, MOP1, PASD8, bHLHe78

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

Member of: DE-10 DE-10.6 Developmental clusters: GC1

Biological processes 134 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity (GO:0001216)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity (GO:0001217)E-box binding (GO:0070888)Hsp90 protein binding (GO:0051879)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulator complex (GO:0090575)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)axon cytoplasm (GO:1904115)axonal transport of mitochondrion (GO:0019896)cellular response to hypoxia (GO:0071456)cellular response to hypoxia (GO:0071456)cellular response to hypoxia (GO:0071456)cellular response to hypoxia (GO:0071456)cellular response to hypoxia (GO:0071456)cellular response to hypoxia (GO:0071456)cellular response to interleukin-1 (GO:0071347)cellular response to oxidative stress (GO:0034599)cellular response to virus (GO:0098586)chromatin (GO:0000785)chromatin (GO:0000785)cis-regulatory region sequence-specific DNA binding (GO:0000987)collagen metabolic process (GO:0032963)collagen metabolic process (GO:0032963)connective tissue replacement involved in inflammatory response wound healing (GO:0002248)connective tissue replacement involved in inflammatory response wound healing (GO:0002248)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)elastin metabolic process (GO:0051541)elastin metabolic process (GO:0051541)enzyme binding (GO:0019899)epithelial to mesenchymal transition (GO:0001837)epithelial to mesenchymal transition (GO:0001837)euchromatin (GO:0000791)histone deacetylase binding (GO:0042826)histone deacetylase binding (GO:0042826)intracellular glucose homeostasis (GO:0001678)intracellular oxygen homeostasis (GO:0032364)intracellular oxygen homeostasis (GO:0032364)motile cilium (GO:0031514)negative regulation of gene expression (GO:0010629)negative regulation of miRNA transcription (GO:1902894)negative regulation of ossification (GO:0030279)negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (GO:1903377)negative regulation of reactive oxygen species biosynthetic process (GO:1903427)negative regulation of reactive oxygen species biosynthetic process (GO:1903427)nuclear body (GO:0016604)nuclear receptor binding (GO:0016922)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)p53 binding (GO:0002039)p53 binding (GO:0002039)p53 binding (GO:0002039)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of angiogenesis (GO:0045766)positive regulation of angiogenesis (GO:0045766)positive regulation of blood vessel endothelial cell migration (GO:0043536)positive regulation of chemokine production (GO:0032722)positive regulation of chemokine-mediated signaling pathway (GO:0070101)positive regulation of cytokine production involved in inflammatory response (GO:1900017)positive regulation of endothelial cell proliferation (GO:0001938)positive regulation of epithelial cell migration (GO:0010634)positive regulation of epithelial cell migration (GO:0010634)positive regulation of erythrocyte differentiation (GO:0045648)positive regulation of gene expression (GO:0010628)positive regulation of gene expression (GO:0010628)positive regulation of gene expression (GO:0010628)positive regulation of glycolytic process (GO:0045821)positive regulation of hormone biosynthetic process (GO:0046886)positive regulation of miRNA transcription (GO:1902895)positive regulation of miRNA transcription (GO:1902895)positive regulation of miRNA transcription (GO:1902895)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of vascular endothelial growth factor production (GO:0010575)positive regulation of vascular endothelial growth factor production (GO:0010575)positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)protein binding (GO:0005515)protein dimerization activity (GO:0046983)protein domain specific binding (GO:0019904)protein heterodimerization activity (GO:0046982)protein heterodimerization activity (GO:0046982)protein kinase binding (GO:0019901)protein-containing complex (GO:0032991)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of gene expression (GO:0010468)regulation of glycolytic process (GO:0006110)regulation of protein neddylation (GO:2000434)regulation of protein neddylation (GO:2000434)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transforming growth factor beta2 production (GO:0032909)response to hypoxia (GO:0001666)response to hypoxia (GO:0001666)response to hypoxia (GO:0001666)response to iron ion (GO:0010039)response to reactive oxygen species (GO:0000302)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)signal transduction (GO:0007165)transcription coactivator binding (GO:0001223)transcription coactivator binding (GO:0001223)transcription corepressor binding (GO:0001222)transcription regulator activator activity (GO:0140537)transcription regulator complex (GO:0005667)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)vascular endothelial growth factor production (GO:0010573)

Expression (TPM)

TFs regulating HIF1A 0 TFs

Transcription factors with Perturb-seq knockdown data for HIF1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HIF1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HIF1A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HIF1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr14:61,427,068–61,427,986	268.1 kb	Distal (>10kb) Multiome	9
	chr14:61,567,895–61,569,162	126.8 kb	Distal (>10kb) Multiome	399
	chr14:61,601,551–61,603,283	93.5 kb	Distal (>10kb) Multiome	299
	chr14:61,694,796–61,696,447	127 bp	At TSS Multiome	933
	chr14:61,750,867–61,751,496	55.7 kb	Distal (>10kb) Multiome	529
	chr14:61,761,767–61,763,093	66.8 kb	Distal (>10kb) Multiome	643
	chr14:61,812,101–61,813,600	117.2 kb	Distal (>10kb) Multiome	261

Genome Browser

Genomic view of the HIF1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.